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Derek Lowe lays out how the trials work, and why they get paused and restarted
Ferrocene is a classic example of a discovery that was dismissed as a failed experiment
The US government’s crackdown on academics not declaring Chinese funding highlights a moral hazard
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
Coronavirus trials reveal the murky reality of disentangling compounds’ effects on human biology
How long will it take to develop a coronavirus vaccine and why is it so hard?
Sometimes you prefer the high-risk, high-reward project to the ‘sure thing’
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity
Assessing the value of researchers’ work is hard, but there are some easy ideas to avoid
Everyone needs a list of ‘things I won’t work with’
Why working on something that’s just ‘interesting’ is not enough
With enough understanding and computing power, it should be possible, but will it happen?
Medicinal chemists need to overcome their fear of fuzzy proteins
Will the giant of structure determination be toppled by blasts from electron beams?
Mechanical helpers have been creeping into our labs for decades
In a complex world, binary answers are often requested but rarely sufficient
Reducing intellectual processes to metrics runs the risk of people working to the numbers not the goal
Can we replicate the chemical profiles of famously expensive drinks? And would people drink them?
Scaling up reactions is easy to get wrong in a variety of ways
Getting more drugs to market is not just a chemistry problem
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