Artificial enzyme sets record as it outperforms horseradish counterpart by factor of 12
Engineered nanoparticle achieves highest efficiency of any artificial enzyme when compared with natural peroxidase
Peptide ligation strategy unlocks diverse range of structural motifs
Approach expected to influence design of protein–protein interaction inhibitors
Click chemistry uses endogenous acrolein to activate cancer prodrug
Strategy could reduce chemotherapy side effects by selecting for cancerous cells
Elemental analysis of skid marks could connect a car’s tyres to a crime scene
New technique could be a valuable addition to forensic scientists’ toolkit
Tri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core
Adding constraints to understand life’s chemical origins
Matt Powner wants to know if there are chemical rules that govern why certain synthetic strategies are embedded in biology
Blocking bacteria’s self-poisoning mechanism weakens their antibiotic resistance
Stopping bacteria from producing hydrogen sulfide in response to drugs could help overcome antimicrobial resistance
Biochemical mystery unfolds as elemental metals found in Alzheimer’s patients’ brains
In a discovery that raises more question than it answers, researchers have found zero-oxidation-state iron and copper deposits inside amyloid plaques
Protein impurities found in AstraZeneca’s Covid-19 vaccine stir debate
Compounds might cause side effects but are unlikely to be behind extremely rare blood-clotting events
Genetically engineered microbes convert waste plastic into vanillin
Plastic bottle becomes industrially useful product thanks to biosynthetic transformation
Coffee pods and 3D printing combine to create cheap and quick Covid-19 tests
Repurposed aluminium capsules enable a point-of-care test ideal for remote and low-income settings
Ingestible COF that delivers insulin could help diabetics duck injections
When blood glucose levels are high, glucose displaces insulin loaded in the framework
Lightning may have created essential building blocks for life on Earth
Reduced phosphorus material discovered in geological sample offers insight into life’s origins
Drink, drugs and disease: the chemistry of breath tests
The growing problem of pesticide resistance
Smart tattoos are keeping tabs on our health
Getting to the root of soil nitrogen
Flow chemistry surges forward
DNA machines get a move on
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Machine learning tool sets out to find new antimicrobial peptides
IBM researchers say their fully automated AI-driven system could speed up the discovery of molecules for novel antibiotics
Pointing the tools of atmospheric chemistry inside
US team monitoring air quality in an on-campus gym detects chemicals in the air that come from cleaning products reacting with sweat
Contact lenses with gold nanoparticles can help correct colour blindness
Soft lenses can correct red–green colour vision deficiency
Thriving wine trade in Islamic Sicily revealed by the chemistry of its pottery
A new method for determining if pottery containers held wine or other grape products could help archaeologist chart the use of the ancient drink
Redox switches up possibilities for signal transduction in artificial cells
Vitamin C triggers membrane translocation in a synthetic system, which generates an amplified fluorescent response
Walking protein’s tiny steps measured with germanium nanospheres
Highest ever resolution measurements suggests answer to kinesin dispute
HPLC alternative purifies peptide cocktails in record time
Reductively cleavable brominated peptide linker unlocks contamination-free traceless release from solid support
Linking chemistry with surgery to detect cancerous cells in situ
Livia Schiavinato Eberlin explains how her team has developed a hand-held device for surgeons that analyses tissue samples on a mass spectrometer mid-operation
Segregation strategy for methane conversion enables new chemical reactivity
Model built to quantify effect of compartmentalisation on organometallic reaction
Nitrogen radical chemistry sees the light
Daniele Leonori explains how his group is taking inspiration from 30-year-old chemistry to devise shorter syntheses for bioactive compounds
How many water molecules make a droplet?
Water molecules behave like bulk water when surrounded by a sea of 20 others