Neural network scours vast chemical space to design drug-delivering peptides
Oligonucleotide drug activity boosted 50-fold with peptide designed by machine learning algorithm
Mirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages
There was more than simple oxygen depletion to ancient mass extinction event
Thallium isotopes reveal that rapid swings in ocean oxygenation preceded the events that wiped out 90% of species 250 million years ago
Enigmatic DNA dubbed ‘Borgs’ discovered in methane-metabolising microbes
The large nucleic acid structures may help bacteria play a role in regulating global methane
Snake extract used to speed up haemostasis in new bioadhesive
Hydrogel-based bioadhesive could be suitable for arterial injuries
Individual cell’s energy metabolism caught on camera for the first time
Combining machine learning with fluorescence imaging provides new insight in glycolysis and might help with development of new therapies for cancer
Method to make unusual oligonucleotides could be a boon for gene therapy drugs
Synthesis can insert unusual linkages into DNA molecules while rivalling industry standard chemistry in speed and efficiency
‘Self-inflating’ synthetic cells can capture, store and release cargo
Entirely artificial system can use chemical energy to ‘swallow’ payloads like bacteria
Giant molecular cage protects plastic-eating enzyme
Caged protein withstands temperatures much hotter than its usual melting point and becomes 1000 times more resistant to solvents
Heavy metal proteins are the secret weapon in ant bites
Protein-rich biomaterials containing zinc, manganese, copper and bromine allow ants, crabs and scorpions to pack more punch for their size
Electrochemical DNA on a chip sensor detects bacterial urinary tract infections faster
Synthetic nucleic acid probes combine with tiny star-shaped electrodes tests for bacteria in less than an hour
Molecular machines talk to living cells for the first time
Artificial molecular motors gently pull on cells’ membrane receptors to trigger a biochemical response
Quantum chemical reaction behind birds’ internal compass
Can migratory robins ‘see’ Earth’s magnetic field at night?
The name’s bond, chemical bond
How a virus ancestor powers our memory’s chemistry
How the power of smell could identify new medical tests
Supermetals versus superbugs
Drink, drugs and disease: the chemistry of breath tests
The growing problem of pesticide resistance
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Sortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
Genetically engineered microbes convert waste plastic into vanillin
Plastic bottle becomes industrially useful product thanks to biosynthetic transformation
Synthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
New class of biomolecule baffles scientists
GlycoRNAs found across several cell types and organisms
Chloroplasts enhanced with artificial dyes adsorb more solar energy
AIEgen-modified chloroplasts can adsorb ultraviolet radiation and increase the efficiency of photosynthesis
Pollen-mimicking antidote saves bees after pesticide exposure
Calcium carbonate microparticles deliver detoxifying enzyme to bees’ guts
Artificial enzyme sets record as it outperforms horseradish counterpart by factor of 12
Engineered nanoparticle achieves highest efficiency of any artificial enzyme when compared with natural peroxidase
Peptide ligation strategy unlocks diverse range of structural motifs
Approach expected to influence design of protein–protein interaction inhibitors
Click chemistry uses endogenous acrolein to activate cancer prodrug
Strategy could reduce chemotherapy side effects by selecting for cancerous cells
Elemental analysis of skid marks could connect a car’s tyres to a crime scene
New technique could be a valuable addition to forensic scientists’ toolkit
Tri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core