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Coca plants’ production pathway for cocaine finally unravelled
167-year-old biosynthetic mystery may be solved
Bioelectric bacteria-powered sensor detects water contaminants in real time
Synthetic biology harnessed to detect endocrine disruptor and thiosulfate
A recipe for biodegradable mushroom batteries
Mycelium skin from wood fungus makes sustainable material for flexible electronics
Artificially expanded genetic alphabet evolves enzymes for the first time
Libraries of short DNA sequences incorporating synthetic nucleotides perform better as enzymes than ordinary DNA
Simple gold salt test for whisky maturity could be round the corner
Formation of gold nanoparticles could track ageing process of whisky and signal when the spirit is ready for bottling
Gut bacterium found to destroy nicotine offers liver health benefits for smokers
Discovery might lead to therapy for non-alcoholic fatty liver disease
AlphaFold works with other AI tools to go from target to hit molecule in 30 days
End-to-end AI drug discovery process predicts potential inhibitors for a protein implicated in liver cancer
Oyster mushroom unleashes chemical warfare on its nematode prey
Fungus discovered to be using 3-octanone to paralyse and kill worms
Molecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
Proteins behind diatoms’ intricate nanoscale-patterned shells revealed
Finding could help pattern materials for photonics, catalysis and sensors
Diverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
NMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
Split-cell design behind batteries that degrade and get absorbed by their environment
Batteries that breakdown on their own could help minimise electronic waste
Omega-3s and brain health
Are everyday chemicals contributing to global obesity?
Celebrating Louis Pasteur’s bicentenary
The brain chemicals that control what we enjoy
How click conquered chemistry
Tiny delivery systems for cancer drugs
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Yeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
Rotting fish experiments reveal how organs fossilise
Most fossils are bones, but individual organs’ biochemistry determines whether they are preserved in rock
Combining expertise to develop remote-controlled nanomaterials
Beatriz Pelaz explains how her research tackles bionanomaterials from multiple angles
Teixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
Antigen-carrying adjuvants activate both adaptive and innate immunity
Aluminosilicate nanoparticles promote ion perturbation, pyroptosis and enhanced immunity in a cancer model
Theories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
Mystery of how plants make strychnine solved 75 years after characterisation
Three-quarters of a century after Robinson and Woodward cracked structure chemists unravel poison’s biosynthesis
Renewable rocket fuel made by genetically engineered soil bacteria
Bioengineered bacteria synthesise extremely energy dense cyclopropane chains
The odour of amity: how you smell can predict friendships
Strangers who smell alike tend to form an instant connection with each other on first meeting
Encapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
Light-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice