![Designed heme-[4Fe-4S] metalloenzyme](https://d1w9csuen3k837.cloudfront.net/Pictures/100x67/8/8/5/138885_heme_index_2.jpg)
Genentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
Blood markers link firefighters' lung disease to WTC attacks
Firefighters who developed lung disease after responding to 11 September attacks in New York connected to specific metabolic profile
Novel fatty acids have exceptional lubricant potential
Chinese oilseed plant offers opportunities for industry
Sound-sensing protein finally found after 35-year hunt
Quest to find the protein responsible for our ability to hear finally appears to be over
Twisting molecule probes cell membrane tension
Changing fluorescence visualises strain in live cells, and reveals unusual behaviour
Reverse liquid sieve lets only large particles pass
Soap film that retains smaller particles while letting bigger ones through could be useful in open surgery or water-free toilets
How chemical evolution took the 2018 chemistry Nobel prize
Emma Stoye has the full story of how Frances Arnold, George Smith and Greg Winter put evolution to work in the lab
Nanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
Healthy animals mimic body odour of sick companions
Sniffer mice and chemical analysis suggest that sickness odours are contagious
Simple test behind early cancer diagnosis breakthrough
Technique combines rolling circle amplification with time-gated Förster resonance energy transfer to detect cancer microRNA
Exotic amino acids made easy with radicals
Stereoselective radical coupling to rival classic Strecker synthesis for easy access to unusual amino acids
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Nerve agents destroyed by self-powering enzyme nanobot
Pumping action of tethered organophosphorus acid anhydrase as it breaks up sarin and Soman is used to release antidote
Bubbly protocells bob up and down
Enzymes inflate or consume oxygen bubbles making clay capsules float and sink reversibly
Fatty acid residues reveal impact of climate change on ancient farming community
Lipid biomarkers help track an extended period of drought that brought societal changes to a Neolithic settlement
How chemical evolution took the 2018 chemistry Nobel prize
The nuclear option
Why are there 20 amino acids?
Medical mass spec
The quest to cure HIV
From folklore to pharmacy
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World’s oldest cheese contained infectious bacteria
3000-year-old cheese found in ancient Egyptian tomb was infected with brucellosis
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Oil-infused plastic gives ketchup the slip
Common packaging materials can be given a non-stick coating inspired by pitcher plants
Prebiotically plausible version of pH gradient generating catalyst
Scientists create simple metal ion system could have facilitated early metabolic processes, like ATP synthesis
MOF detox could save aspirin overdose patients
Detoxifying metal–organic framework removes dangerous doses of salicylic acid from rats’ guts
Artificial intelligence seeks out new anticancer drugs
A combination of machine learning methods yields promising results for drug discovery
AI tool could save on animal tests
Algorithm could also help unravel poisoning or environmental contamination cases
Supramolecular system refines enzyme impression
Metalloenzyme mimic combines a guest binding pocket, a well-defined coordination sphere and an internal base to achieve impressive catalytic control
Enzyme survives blistering conditions to rapidly break down cellulose
Ionic liquid protects enzyme as it turns woody biomass into sugars 30 times faster than previously possible
Parasitic self-replicating molecules consume their creators
Simple chemicals display life-like behaviour
Four step route to carbotricycles
Elegant strategy that directly assembles 5–8–5 scaffolds from simple precursors paves way to a new library of bioactive compounds
Tool to navigate chemical space aims to be ‘Google Maps of drugs’
Software allows links between 8000 drugs and 47,000 compounds of environmental concern to be explored in 3D
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