Computational method challenges NMR metabolomics dogma
Macromolecule signal suppression without the loss of quantitative small molecule information finally achieved with mathematical trick
Unnatural reaction benefits from computational tool that teaches an old enzyme new tricks
Method could generate artificial enzymes that are more suitable for directed evolution
Unprecedented biosynthetic transformation found to connect antibacterial polyketides from ant microbiome
Study identifies enzymes that convert flat fasamycins into three-dimensional formicamycins
Algorithm devises synthetic contingency plans for Covid-19 drug
Retrosynthesis software tool can identify multiple synthetic routes that use inexpensive and diverse starting materials while avoiding patented methods
Drone blows clouds of pollen laden bubbles that could help farmers out
Automated bubble-firing drones could pollinate crops when insects numbers are down
Proteins pinpointed in cells at nanometre resolution
Combining fluorescence microscopy and electron tomography will reveal more about how cells work and how diseases disrupt them
Mass spectrometry and augmented reality guide tumour removal in real time
Colour pixels help surgeons differentiate between cancerous and healthy tissue
Twists of orange odorant reveal smell secrets
Modifying octanal produces hard-to-get information about olfactory receptors
Translating snail venom research from beach to bench and beyond
Meet Mandë Holford, an interdisciplinary scientist following tangents that arise when exploring the molecular-level workings of venom peptides
Rare trehalulose sugar found in stingless bee’s honey
Stingless bee honey could be beneficial for diabetes patients as our body digests trehalulose more slowly than sucrose
Method that yields oxygen-18-enriched alcohols set to bolster drug studies
Mitsunobu-based protocol is simple alternative to limited and lengthy methods
Protein synthesis revolution on way as large peptides made in hours not days
Flow chemistry can now make peptide chains up to 164 amino acids long in one go
Respiratory viruses detected in 30 minutes with the help of a smartphone
$50 smartphone accessory could be adapted for Covid-19
Why is cystic fibrosis so hard to treat?
The function of folding
Metalloenzyme mastery
The difficulties of drugging our brains
Drugging the gut microbiome
Uncovering how the spliceosome makes the cut
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First natural Diels–Alder enzyme discovered in mulberry tree
Enzyme beats most synthetic catalysts when it comes to enantioselective intermolecular [4+2] cycloadditions
Photosynthesis rewired to generate hydrogen
Gene transplant repositions algal hydrogenase so that it directly captures electrons from photosystem I
Artificial chloroplasts turn CO2 into multicarbon molecules, powered only by light
Microfluidic platform opens up non-natural metabolic pathways
Six-month validation behind polymer that prevents biofilm growth
Zwitterionic surface could cut infections by repelling bacteria
Sugar shack test set to flip procedure for maple syrup quality control
Plasmonic tongue sensor checks maple syrup flavour in minutes
Yeast thriving in hydrogen hints at possibility of life on exoplanets
First demonstration of non-adapted microorganisms growing in 100% H2 shows that life could exist even under seemingly hostile conditions
Introducing chirality to give organic electronics a twist
Medicinal molecules and electronic materials aren’t often found in the same research group. Meet Matthew Fuchter, who’s excelling at both
Trapped enzyme reveals its unexpected shape-shifting ability
Metamorphic protein confined in nanopore found to switch between different 3D shapes as it catalyses a redox reaction
MOF delivers cancer drug candidate straight to mitochondria
New ‘Trojan horse’ strategy could reduce drug doses needed to kill cancer cells
Enzymes encapsulated in a golden cage perform in extreme conditions
No room for the proteins to denature but reactants can still get through
Has mystery of why benzene forms in cherry-flavoured soft drinks been solved?
Photochemical reaction discovery points to simple way to prevent formation of the carcinogen