Antigen-carrying adjuvants activate both adaptive and innate immunity
Aluminosilicate nanoparticles promote ion perturbation, pyroptosis and enhanced immunity in a cancer model
Theories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
Mystery of how plants make strychnine solved 75 years after characterisation
Three-quarters of a century after Robinson and Woodward cracked structure chemists unravel poison’s biosynthesis
Renewable rocket fuel made by genetically engineered soil bacteria
Bioengineered bacteria synthesise extremely energy dense cyclopropane chains
The odour of amity: how you smell can predict friendships
Strangers who smell alike tend to form an instant connection with each other on first meeting
Encapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
Split-cell design behind batteries that degrade and get absorbed by their environment
Batteries that breakdown on their own could help minimise electronic waste
Yeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
Fox urine compound as good as catnip for some felines
Dihydroactinidiolide is the first example of a compound excreted by a mammal that can elicit a catnip response
Crispr editing of certain genes could trigger cell death
Researchers identify more than 3000 spots in the human genome where gene editing could cause toxic side effects and genomic instability
Light-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
Fossil molecules reveal dinosaurs’ bird-like metabolism
Thioethers preserved in bones show that most dinosaurs were warm-blooded, though T rex may have been particularly sluggish
Breaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
Can we clean Covid from the air around us?
50 years of artemisinin
The plant trade’s scientific secrets
Cultured meat flexes its muscles
How a murder and a bombing cleaned up DNA profiling
Using genetics to personalise prescriptions
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Gene therapy showcases technique to extend life in mice
Lab mice lived significantly longer after receiving one of two genes, delivered using a mouse herpes virus
Life’s handedness could have arisen spontaneously on Earth
New insight into the origins of homochirality point to adaptation to energy sources as driver
AI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
Yeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
Freeze–thaw cycles could explain how ancient RNA replicated without enzymes
Discovery solves puzzle of RNA world hypothesis
Controlling chemistry of chocolate making could speed up process without compromising taste
Non-microbial way to make chocolate that might supplant fermentation
AI tool finds green ways to turn chemical waste into drugs
Circular approach for industry by-products considers environmental, economic and geographic aspects to rank predicted routes for real-world applications
Edible, fluorescent silk tags could help stem tide of counterfeit medicines
Marker could be a simple answer to ensuring provenance of drugs
Pepto-Bismol compound’s structure unveiled after 120 years
Electron microscopy triumphed over x-ray crystallography as century-old structural puzzle around bismuth subsalicylate is finally solved
Discovery of microplastics in people raises difficult questions about health implications
Scientists keep finding tiny polymer particles in lungs, blood and placentas – but what does that mean means for people’s health?
Sea sponges own unique chemistry goes beyond that of their bacterial guests
Biologically potent compounds can be made by sea sponges themselves