All Natural products articles
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ResearchStreamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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Research
Chirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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Research
Controversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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Feature
50 years of artemisinin
Jamie Durrani tells the story of how a wonder drug against malaria was discovered from a plant in a secret Chinese military project
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Research
Clever carbene synthesis replaces notoriously hazardous chemistry
Reactive carbon compounds can now be made from aldehydes instead of explosive or unstable reagents
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Business
Soapbark branches out to fill essential role in vaccine recipes
The soapbark tree has long been used in traditional medicines, but is now coveted for some of our newest vaccines
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Opinion
Exit strategy
Overcoming a major setback showed Derek Lowe could make it through graduate school
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Opinion
Taking the right inspiration from nature
Scientists need to be selective about their sources of inspiration
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Research
Exploiting evolution to explore chemical space shows promise for drug discovery
Using molecular trees – similar to family trees – chemists could predict how products will evolve to make new molecules
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Research
Ultraphosphates break decades-old anti-branching rule
Discovery of elusive branched phosphates’ unexpected stability means they could have played a role in prebiotic chemistry
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Research
Blue light squeezes out heteroatoms from small rings
Photochemical ring editing reaction allows complete molecular shape change in a single step
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Research
Molecular cryo-EM discovers error in 25-year-old natural product structure
Nobel prize-winning biomolecule imaging technique adapted to characterise chemical compounds faster and easier than NMR and x-ray
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Research
Newly discovered marine compound is in a super-carbon-chain league of its own
Isolated from algae, Benthol A has 35 stereocentres
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Research
Machine-designed natural product syntheses pass ‘Turing test’ for chemistry
Software updates allow Chematica to design sophisticated synthetic pathways, planning each step four or five moves ahead
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Podcast
Glycyrrhizic acid
A sweet treat with a deadly trick for Halloween – glycyrrhizic acid is found in black liquorice and sweeter than sucrose, but can cause heart problems and even prove fatal if consumed in excess
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Opinion
Ghanaian biochemistry TV star Marian Addy
Marian Addy was the first female science professor in Ghana, who studied herbal medicine – and was a TV star
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Research
First natural Diels–Alder enzyme discovered in mulberry tree
Enzyme beats most synthetic catalysts when it comes to enantioselective intermolecular [4+2] cycloadditions
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Research
Chemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies
