Natural products – Page 2
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OpinionTaking the right inspiration from nature
Scientists need to be selective about their sources of inspiration
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ResearchExploiting evolution to explore chemical space shows promise for drug discovery
Using molecular trees – similar to family trees – chemists could predict how products will evolve to make new molecules
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ResearchUltraphosphates break decades-old anti-branching rule
Discovery of elusive branched phosphates’ unexpected stability means they could have played a role in prebiotic chemistry
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ResearchBlue light squeezes out heteroatoms from small rings
Photochemical ring editing reaction allows complete molecular shape change in a single step
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ResearchMolecular cryo-EM discovers error in 25-year-old natural product structure
Nobel prize-winning biomolecule imaging technique adapted to characterise chemical compounds faster and easier than NMR and x-ray
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ResearchNewly discovered marine compound is in a super-carbon-chain league of its own
Isolated from algae, Benthol A has 35 stereocentres
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ResearchMachine-designed natural product syntheses pass ‘Turing test’ for chemistry
Software updates allow Chematica to design sophisticated synthetic pathways, planning each step four or five moves ahead
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PodcastGlycyrrhizic acid
A sweet treat with a deadly trick for Halloween – glycyrrhizic acid is found in black liquorice and sweeter than sucrose, but can cause heart problems and even prove fatal if consumed in excess
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OpinionGhanaian biochemistry TV star Marian Addy
Marian Addy was the first female science professor in Ghana, who studied herbal medicine – and was a TV star
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ResearchFirst natural Diels–Alder enzyme discovered in mulberry tree
Enzyme beats most synthetic catalysts when it comes to enantioselective intermolecular [4+2] cycloadditions
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ResearchChemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies
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PodcastHydroquinone
Georgia Mills on a compound that explodes from a beetle’s bum, and has a controversial role in skin depigmentation
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Research‘Inside-out’ chirality discovered by chance could have been missed in many molecules
A structure assignment odyssey finds a natural product with a type of isomerism never before seen in small molecules
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PodcastVitamin B12 or Cobalamin
If you’re trying out a vegan diet, you’re likely to be told to make sure you get enough vitamin B12. But what is B12, where do we get it from, and how can we be sure we’re getting enough?
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ResearchProgram finds 5 million synthetic routes to complex chemicals
Only around five hundred ‘tactical combinations’ for advanced organic synthesis existed – until Chematica was let loose on the problem
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PodcastIminosugars
After some promising results treating ill pets, some researchers think iminosugars could become treatments for infection and even cancer. Mike Freemantle explores the buzz around iminohoney
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NewsOpen access Atlas maps out microbial natural products
Project aims to accelerate research on microbial metabolites
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