New electron diffraction strategy could make it easier to study solvated organic microcrystals

A chemical structure

Source: © Niko Vlahakis et al, ChemRxiv 2025

The approach combines carbon liquid cells and rapid data acquisition to study solvated molecules at room temperature

A new electron diffraction method determines the room-temperature structures of solvated organic molecular microcrystals, according to a team of US-based researchers. The approach, which is presented in a preprint report and has not yet been peer reviewed,1 could make it easier for researchers to study molecules that need to remain solvated at all times, opening new opportunities in chemical and pharmaceutical research.