All Pharmacology articles
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ResearchLipophilicity helps explain psychedelic drugs’ therapeutic effects
Understanding why psychedelic drugs that bind to serotonin receptors promote neuron growth, while serotonin itself does not
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Research
Molecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
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News
Alarm sounded after chemists discover new analogue of ketamine in Australia
Long-term health effects of novel psychoactive substance are unknown
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Feature
Using genetics to personalise prescriptions
We’ve known for a long time that different people respond to certain drugs to very different extents, but now cheap DNA testing could make these disparities a thing of the past, as Ian Le Guillou reports
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News
Drug discovery AI that developed new nerve agents raises difficult questions
Researchers shocked by how easily algorithm discovered novel poisons even deadlier than VX
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Research
Sulfonated macrocycle helps the medicine go down
A supramolecular approach makes alkaloid drugs taste less bitter
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Research
Tiny shear forces have big effect on protein reactions
Proteins react faster under the forces they experience when they squeeze through blood vessels
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Research
Protein impurities found in AstraZeneca’s Covid-19 vaccine stir debate
Compounds might cause side effects but are unlikely to be behind extremely rare blood-clotting events
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Opinion
The side effects of being unique
Even the largest clinical trials won’t capture all possible bad reactions to a drug – we need pharmacovigilance
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Business
Antibody–drug conjugates drive growth in oncology
Antibody–drug conjugates are coming of age and pharma is investing, reports Katrina Megget
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Research
Peptides self-assemble to support growth of artificial tumours
Cancer cells grown around bioengineered microfibres make an ideal model to test new chemotherapy drugs
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News
Caution urged as scientists await results of trial that finds steroid cuts Covid-19 deaths
Claims that 60-year-old drug dexamethasone dramatically lowers fatality rate of seriously ill Covid-19 patients await peer review
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Research
Method that yields oxygen-18-enriched alcohols set to bolster drug studies
Mitsunobu-based protocol is simple alternative to limited and lengthy methods
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Research
Database offers another way to search for drugs – by activity not structure
Dataset offers new way for biomedical researchers to identify potential drug candidates
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Podcast
Interferon beta
An immune-modulating compound used to reduce the symptoms of multiple sclerosis and now showing potential against coronaviruses
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News
Science steps up a gear as struggle to both understand and fight coronavirus intensifies
Research that might have taken years is being turned around in months as journals fast-track Covid-19 manuscripts
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Research
AI tool screens 107 million molecules, discovers potent new antibiotics
Deep learning approach could help in fight against drug-resistant bacteria
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