All Protein folding articles
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NewsExplainer: Why have protein design and structure prediction won the 2024 Nobel prize in chemistry?
Research that has taken us from sequence to structure and back again
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OpinionBeing wrong is almost inevitable
On the tightrope of expressing your opinion, you always risk looking a fool
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OpinionProteins’ shape and function are two sides of the same coin
A new perspective on the relationship between chemistry and biology
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ResearchNanopore proteins designed from scratch and turned into biosensors
Artificial ion channels used to detect disease indicators and pharmaceuticals
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ResearchDeep learning algorithm predicts structures of biomolecular assemblies
RoseTTAFold extended to predict structures of proteins bound to small molecules
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ResearchProtein folding stability set to be unravelled on a massive scale
Technique can analyse a million protein sequences at a time to provide data for machine learning models
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FeatureChanging the game in protein structure prediction
Have AlphaFold and other machine learning techniques essentially solved the formerly fiendish problem, or is there still more to be done? Clare Sansom reports
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BusinessEncoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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OpinionExploring AlphaFold’s knowledge of energy landscapes
The algorithm needs a little help to find the global energy minimum
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ResearchNanoplastics disrupt ubiquitination in human cells
High-resolution study mapping nanoparticle–protein interactions builds understanding surrounding health implications of plastic contamination
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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NewsAlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe
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OpinionBeyond the transition state
Entropy production could be a key guide to predicting how a reaction product forms
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OpinionThe law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery
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ResearchGel-forming proteins could help tardigrades survive extreme conditions
Biophysical dissection of tardigrade’s disordered protein could uncover how microscopic animals survive conditions that kill most other forms of life
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ResearchTiny shear forces have big effect on protein reactions
Proteins react faster under the forces they experience when they squeeze through blood vessels
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NewsMachine learning delivers ‘human genome’ moment for proteins
Protein structure prediction tools AlphaFold and RoseTTAFold take the latest steps towards maturity and make their software open source
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OpinionBehind the screens of AlphaFold
Predicting protein structure doesn’t necessarily say much about function
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ResearchGoogle’s AI aces protein prediction competition
Deep-learning network AlphaFold2’s perfomance at predicting how proteins fold has caused great excitement in the scientific community
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ResearchProtein synthesis revolution on way as large peptides made in hours not days
Flow chemistry can now make peptide chains up to 164 amino acids long in one go