All Protein folding articles
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FeatureChanging the game in protein structure prediction
Have AlphaFold and other machine learning techniques essentially solved the formerly fiendish problem, or is there still more to be done? Clare Sansom reports
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Business
Encoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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Opinion
Exploring AlphaFold’s knowledge of energy landscapes
The algorithm needs a little help to find the global energy minimum
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Research
Nanoplastics disrupt ubiquitination in human cells
High-resolution study mapping nanoparticle–protein interactions builds understanding surrounding health implications of plastic contamination
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Opinion
Why AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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News
AlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe
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Opinion
Beyond the transition state
Entropy production could be a key guide to predicting how a reaction product forms
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Opinion
The law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery
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Research
Gel-forming proteins could help tardigrades survive extreme conditions
Biophysical dissection of tardigrade’s disordered protein could uncover how microscopic animals survive conditions that kill most other forms of life
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Research
Tiny shear forces have big effect on protein reactions
Proteins react faster under the forces they experience when they squeeze through blood vessels
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News
Machine learning delivers ‘human genome’ moment for proteins
Protein structure prediction tools AlphaFold and RoseTTAFold take the latest steps towards maturity and make their software open source
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Opinion
Behind the screens of AlphaFold
Predicting protein structure doesn’t necessarily say much about function
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Research
Google’s AI aces protein prediction competition
Deep-learning network AlphaFold2’s perfomance at predicting how proteins fold has caused great excitement in the scientific community
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Research
Protein synthesis revolution on way as large peptides made in hours not days
Flow chemistry can now make peptide chains up to 164 amino acids long in one go
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Opinion
Embracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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Opinion
Bringing video games into the protein fold
Citizen scientists use a computer game to design brand new proteins
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Research
Neural network folds proteins a million times faster than its competitors
Machine learning algorithm that predicts protein structures in milliseconds could top next protein folding contest
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Research
Synthetic molecules fold up into abiotic proteins
Compound that self-assembles into giant folded ring could help scientists design bespoke abiotic proteins
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Opinion
Powers of prediction
If the terrifyingly difficult problem of protein folding is getting closer to a solution, what other intractable problems are ripe for answering?
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Feature
Go with the fold
From a seemingly impossible problem a few years ago, some researchers think that predicting the folded structures of protein could be solved pretty soon. James Mitchell Crow reports
