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NewsScientists hope to illuminate unknown human proteins with new public database
‘Unknome’ database contains thousands of understudied proteins
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ResearchProtein folding stability set to be unravelled on a massive scale
Technique can analyse a million protein sequences at a time to provide data for machine learning models
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NewsBillionaire professor donates ‘transformative’ sum to protein science institute
$210 million endowment from entrepreneur and Moderna investor Tim Springer will support ongoing research
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ResearchOptical microscopy with Ångström resolution could revolutionise how we see life
Technique can distinguish between details that are just a few atoms apart
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ResearchNMR reveals sialic acid biosynthesis in real time
Using NMR, scientists can directly measure sialic acid enzyme conversion velocities for the first time
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ResearchWoodcock feathers’ nanostructure makes them the whitest ever found
The Eurasian woodcock’s white tail feathers reflect up to 55% of light –30% more than those of any other bird
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FeatureChanging the game in protein structure prediction
Have AlphaFold and other machine learning techniques essentially solved the formerly fiendish problem, or is there still more to be done? Clare Sansom reports
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ResearchProteins behind diatoms’ intricate nanoscale-patterned shells revealed
Finding could help pattern materials for photonics, catalysis and sensors
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OpinionExploring AlphaFold’s knowledge of energy landscapes
The algorithm needs a little help to find the global energy minimum
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ResearchNanoplastics disrupt ubiquitination in human cells
High-resolution study mapping nanoparticle–protein interactions builds understanding surrounding health implications of plastic contamination
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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OpinionWhy glycans?
Glycoscience is turning out to be more interesting than anyone might have imagined
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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ResearchTeixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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NewsAlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe
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FeatureThe incredible antibodies of sharks, llamas and camels
Sharks and llamas share a strange quirk of their immune systems. Hayley Bennett finds out how their ‘nanobodies’ could help us tackle Covid and a host of other diseases
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ResearchBiochemical secrets of tarantula’s painful bite could point to perfect painkillers
King baboon spider venom could help scientists develop potent analgesics
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ResearchGel-forming proteins could help tardigrades survive extreme conditions
Biophysical dissection of tardigrade’s disordered protein could uncover how microscopic animals survive conditions that kill most other forms of life
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InformationScience behind sense of touch and temperature wins medicine Nobel prize
David Julius and Ardem Patapoutian honoured for discovery of ion channels activated by temperature and mechanical force
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ResearchHeavy metal proteins are the secret weapon in ant bites
Protein-rich biomaterials containing zinc, manganese, copper and bromine allow ants, crabs and scorpions to pack more punch for their size