Molecular labels streamline high throughput mass spec analysis by rapidly ranking reactions

A generalised mass spectrometry method leverages electrophilicity to rapidly rank reaction outcomes in experimental screens. The new approach attaches a nucleophilic tag to the product molecules, creating a common chemical fingerprint which is then easily detected in the subsequent analysis. This simplified detection step evaluated samples more than 60 times faster than conventional analytical methods and addresses a key bottleneck in high throughput experimentation and compound library generation.