Tri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core
Researchers in the US have developed a three-pronged molecule that simultaneously activates three different types of immune receptor. In vitro and in vivo tests found that the molecule provoked a robust immune response by mimicking how invading pathogens trigger several pathways to initiate protective immunity. The team behind the work suggest their modular concept could be adapted to create potent vaccine adjuvants for various infectious diseases.