Organic chemistry
The latest chemistry news and research on organic chemistry, including synthesis, natural products and total synthesis, reaction mechanisms and supramolecular chemistry, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchBridging the gap between Hammett parameters and the electronic structure of aromatic systems
Occupation of effective atomic orbitals used to quantify and predict Hammett parameters
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ResearchFilter paper simplifies squaramide synthesis
Capillary-driven flow distributes reagents evenly
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ResearchSkeletal editing provides quick access to pharmaceutical ‘matching pairs’
Late-stage functional group switching in dibenzofurans will aid drug discovery chemistry
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NewsWhy does asparagus make my urine smell?
The chemistry of the organosulfur compounds that result in a fragrant toilet
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ResearchLSD analogue synthesised by swapping just two atoms less likely to cause hallucinations
New molecule shows promise for treating neuropsychiatric conditions such as schizophrenia
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ResearchCascade reaction brings a new dimension to amine synthesis
Method creates two new rings and four new bonds
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ResearchCatenane with tuneable mechanical chirality created
The chirality of a compact cationic catenane can be controlled using chiral sulfonate anions
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ResearchReimagining synthetic strategy with skeletal editing ticks box on chemists’ wish list
Selective heteroatom alkylation offers route to modify important drug building blocks
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ResearchLight-activated catalyst sorts mirror-image molecules by resetting carbon–halogen bonds
Photocatalytic reaction that inverts chiral centres offers new way to enrich racemic mixtures
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Research‘Bowtie-shaped’ molecule displays spin entanglement
A new solution synthesis strategy could catapult quantum applications
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ResearchSpray-drying investigated as a speedy method for synthesising small organic molecules
Technique applied to Schiff-base condensations, Claisen–Schmidt reactions and amine acylations
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ResearchLong-chain alkanes preserved in Martian mudstone
Molecules could have derived from biological fatty acids, although abiotic origins are also possible
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
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ResearchStudy challenges notion that solution-phase organic reactions are unfeasible at high temperatures
Capillary synthesis at 500°C converts N-substituted pyrazoles into their isomers within five minutes
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ResearchUnusual radical reaction powered by strained substrates
Single-electron strain-release produces pharmaceutical building blocks
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ResearchForbidden electrocyclic reactions can be more allowed than previously thought
Study suggests such reactions should instead be described as either ‘Woodward–Hoffmann favoured’ or ‘Woodward–Hoffmann disfavoured’
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ResearchTotal synthesis of anti-addictive alkaloid in just seven steps
A streamlined synthesis of the psychoactive compound ibogaine could open up new opportunities in the treatment of drug addiction and depression
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FeatureMelanie Sanford’s route from college gymnast to groundbreaking researcher
One-time gymnast Melanie Sanford has made a name for herself in catalysis and organometallic chemistry. Rebecca Trager charts her path to success, from her mentors to her mentoring
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OpinionFluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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Opinion(–)-Scabrolide B (again!)
Proverbially, comparison may not bring joy – but it can be educational