All Organic chemistry articles
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Feature
The search for the grand unification of aromaticity
Researchers have been trying to find a full definition of aromaticity for almost two centuries, and yet keep discovering new types. Katrina Krämer asks when chemists will get to the bottom of this elusive concept.
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Research
Newly discovered marine compound is in a super-carbon-chain league of its own
Isolated from algae, Benthol A has 35 stereocentres
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Research
Molecular light switch speeds up tricky cyclodextrin synthesis
Reaction could lower cost of useful macrocycle
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Research
Chemists reconsider C–H and C–C bond length rationale
Quantitative proof for steric repulsion theory
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Research
Glass catalysis screening study prompts reactionware rethink
Base-catalysed reactions are up to 1000 times faster in the presence of glass
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Research
Origin of mysterious alpha effect in nucleophilic substitution reactions unveiled
Alpha nucleophiles’ ability to get close to electrophiles – rather than their intramolecular lone pair repulsion – gives them unusual reactivity
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Research
From nerve agent simulant, to pharma ingredient
Portable microreactor offers a new way to dispose of paraoxon
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Research
Sortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
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Research
Nanomaterial stores radicals to power photopolymerisation in the dark
Reaction driven by long-lived radicals experiences fewer side reactions than photopolymerisation under light irradiation
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News
Chemistry Nobel laureate Ei-ichi Negishi dies at 85
Discoverer of the Negishi coupling, who did synthetic organic chemistry research at Purdue for four decades, has passed away
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Research
Genetically engineered microbes convert waste plastic into vanillin
Plastic bottle becomes industrially useful product thanks to biosynthetic transformation
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Research
Synthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
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Research
Blue light triggers ‘unprecedented’ reaction in old catalyst
Traditional iridium intermediate switches from allylic substitution to cross coupling when exposed to blue light
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Opinion
Free radicals for post-translational modification
A technique for forming new carbon–carbon bonds at specific sites in proteins
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Research
Reaction confined between copper nanopyramids transforms carbon dioxide into ethylene glycol
Copper arrangement promotes C–C coupling and lowers formation barrier for a key intermediate
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Feature
Computer-guided retrosynthesis
Machine learning-based systems hope to outperform expert-guided reaction planning technology, finds Andy Extance
