All Organic chemistry articles
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ResearchSynthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
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Research
‘Inside-out’ chirality discovered by chance could have been missed in many molecules
A structure assignment odyssey finds a natural product with a type of isomerism never before seen in small molecules
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Research
Mixed oxidation states expand repertoire of hypervalent iodine reagents
Iodine(iii) and iodine(v) coexist in new nitroiodoxybenzene-based oxidant
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Research
Program finds 5 million synthetic routes to complex chemicals
Only around five hundred ‘tactical combinations’ for advanced organic synthesis existed – until Chematica was let loose on the problem
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Feature
Can chemists crack our cells’ sugar code?
Rachel Brazil talks to the scientists trying to understand the sweet mystery of the glycome
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Research
Total synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
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Research
Simple way to construct molecules with perfluoroalkyl bridges
Troublesome side reaction becomes useful synthetic tool
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Opinion
Cleaning up chemical kitchens
In a busy plant, ensuring small changes don’t produce unforeseen toxic impurities is key
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Research
Flow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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Research
Total synthesis of unnatural enantiomer renews interest in quinine
Scientists hope their strategy will invigorate cinchona alkaloid-mimic catalysis
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Research
Chemists taken aback as dinitrogen found to speed up some reactions
Warnings that nitrogen should no longer be considered just an inert carrier gas
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Research
Biomimetic synthesis cultivates yellow poppy pigment
Cascade process that fuses indole with orientalin verifies biosynthesis of nudicaulins
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Research
Steric shield leads boron to aromatic rings’ most remote region
Bulky blocking counterion makes quick work of borylating arenes’ inaccessible para position
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Opinion
(±)-Rhabdastrellic acid A
A triterpene that looks innocuous until it reveals the highly strained conformation of its rings
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Research
Light intensity changes can switch photocatalyst between one- and two-photon mechanisms
Simple optical lens behind strategy for manipulating photochemical reactivity
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Research
Lignin and carbon dioxide turned into ethanol
Process generates bulk chemical from two renewable carbon sources
