Organic chemistry
The latest chemistry news and research on organic chemistry, including synthesis, natural products and total synthesis, reaction mechanisms and supramolecular chemistry, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchProbability model guides synthesis of interwoven catenane structure
Organic cage-like compounds selectively form intricate structure during one-pot synthesis
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WhitepaperOptimise cross-coupling with ligand-free NHC–Pd precatalysts
Discover how new NHC–Pd precatalysts deliver superior performance without stabilising ligands
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ResearchParamagnetic NMR used to probe covalent character of halogen bonds
Assessing hyperfine shifts in paramagnetic NMR spectra provides new details on the covalent character of halogen bonded cocrystals
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ResearchStable nitrogen chiral centres are possible – under the right conditions
Chiral nitrogen compounds might one day be used as reagents, catalysts or even as drugs
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OpinionA robotic helping hand
Mechanical labmates are making huge progress, but there are still big challenges to overcome
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ResearchModular strategy opens up new way to synthesise arylated thiophene rings
Approach holds potential for creating new drugs and unique optoelectronic materials
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ResearchInfrared and NMR fusion boosts automated structure verification
Study highlights untapped potential of IR spectroscopy data
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ResearchA current take on the Swern oxidation
Electrochemical update to a classic reaction trades cryogenic conditions for room temperature, to selectively convert primary and secondary alcohols into aldehydes and ketones
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NewsUK’s new national laboratories site will support ‘invisible infrastructure’ of measurements that keep world in sync
£20 million investment by LGC will boost country’s analytical and metrology capabilities
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Opinion(−)-Novofumigatonin
Oxidations abound in this satisfying synthesis, with a delicate nitrile hydrolysis to finish
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ResearchQuantum tunnelling drives aromaticity flip-flop
Augmented pentalene structure could be a molecular Schrödinger’s cat, aromatic and antiaromatic at the same time
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ResearchThis fragment-based drug discovery library is designed to be sociable
Study targets a key bottleneck in hit to lead optimisation by designing fragments that are both structurally diverse and easy to elaborate
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ResearchAll stirred up: chemical engineers refute claims that ‘stirring doesn’t matter’
Failing to mix reactions in heterogeneous or industrial systems could cause numerous issues and might even be dangerous, preprint claims
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ResearchDihydropyrazine-embedded macrocycles behave like supersized cycloalkanes
Giant molecular rings that mimic the puckered shapes of cyclobutane, cyclopentane and cyclohexane could offer new insights into conformational dynamics
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Research‘Stimulating discovery’ leads to strategy to swap oxygen in saturated rings
Skeletal editing pushed beyond aromatic structures, sparking new opportunities in drug discovery
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WebinarSYNTHIA for chemists: faster route design
Join us on 11 December to discover how SYNTHIA accelerates retrosynthesis by helping chemists design, compare and refine routes with customisable filters and commercial building blocks
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OpinionMy arcane and curious connection to metal-organic frameworks
Fernando Gomollón-Bel uncovers a link between his hometown and the 2025 Nobel prize in chemistry
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NewsMeet the three scientists who have just won the Nobel prize in chemistry
Learn about the lives of newly minted chemistry Nobel laureates Susumu Kitagawa, Richard Robson and Omar Yaghi
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NewsExplainer: why have metal–organic frameworks won the Nobel prize in chemistry?
Susumu Kitagawa, Richard Robson and Omar Yaghi scooped the Nobel prize for their work on MOFs – here’s everything you need to know
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News2025 chemistry Nobel prize goes to the scientists behind metal–organic frameworks
Susumu Kitagawa, Richard Robson and Omar Yaghi take top prize for discovery and development of versatile materials with a huge surface area