All Organic chemistry articles
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ResearchNew approach to make chiral amines from internal olefins revealed
Clever reaction design enables the direct addition of N–H bonds to unactivated internal alkenes with high enantioselectivity
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Research
Big data behind cheat sheets for optimising Buchwald–Hartwig cross-couplings
Interactive tools based on data from 62,000 reactions could help chemists eliminate human biases when selecting reaction conditions
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Research
Machine-learning software competes with human experts to optimise organic reactions
Researchers say the tool is an inexpensive approach to yield optimisation for chemistry labs that can’t afford robots
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Research
Machine-designed natural product syntheses pass ‘Turing test’ for chemistry
Software updates allow Chematica to design sophisticated synthetic pathways, planning each step four or five moves ahead
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Research
Elusive formyloxyl radical hints at unique, and more sustainable, chemical transformations
An electrocatalytic route for forming the formyloxyl radical in situ enables researchers to probe its unexpected chemistry
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Research
Porphyrin assembly is ‘largest pure organic synthetic cage’ ever made
Hollow structures could find use in light harvesting or cargo-trafficking systems
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Research
Traditional olefin hydroboration yields surprising trans-isomers
A very common organic reaction under ordinary conditions has produced significant amounts of unexpected trans-products for the first time
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Research
Hammett equation parameters optimised for improved predictive power
Update overcomes limitations and eliminates human biases intrinsic to the original formulation
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Research
Diels–Alder study casts doubt on innate endo-selectivity
New evidence questions the Alder endo rule of simple Diels–Alder reactions
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Research
Superbenzenes now do the twist too
Supertwistacene is the first configurationally stable chiral graphene nanoribbon
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Research
Universal chemistry software can turn words into chemicals
System could be the beginning of a brave new world of democratised chemistry
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Research
Chiral benzyne made with single handedness for the first time
First enantioenriched aryne atropisomer can create chiral nanographene and anthracene structures
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Opinion
Fully automated synthesis of fluorine-18 PET tracers
Making radioisotopes suitable for positron emission tomography
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Research
Algorithm discovers how six simple molecules could evolve into life’s building blocks
Program shows how micelles, catalysts and self-replicating chemical systems emerge from abiotic precursors
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Feature
Homogeneous C–H activation
In the final instalment of our grails series we look at how picking and choosing which bond to target holds the promise of transforming organic molecules at will
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Research
Carbon bond formation reproducibility runs into reagent stability problem
Solid sodium alkoxides react with carbon dioxide and can hamper performance – but sometimes improve it
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Research
DNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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Research
Ultra-fluorinated cyclohexane shows off two faces
1,2,3,4,5,6‐hexakis(trifluoromethyl)‐cyclohexane is the most sterically crowded all-cis derivative
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Research
Aniline synthesis turns to photochemistry to access challenging targets
New photochemical strategy could jump in where common cross-coupling reactions fall short
