Organic chemistry
The latest chemistry news and research on organic chemistry, including synthesis, natural products and total synthesis, reaction mechanisms and supramolecular chemistry, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchStudy points to ammonia contamination in water microdroplets saga
Replication effort attributes mass spectrometry peaks to ammonium not hydroxyl species
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ResearchElusive electronic effect could explain the origins of chirality for all life on Earth
Study suggests spin selectivity is different in enantiomers – altering their reaction rate – which ‘challenges a fundamental assumption in the field’
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ResearchElectrifying MOF synthesis drastically reduces time it takes to make them
External electric fields stimulate the formation of various metal–organic framework materials
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Research‘Flip-over’ nucleophilic substitution reaction challenges classic SN2 textbook mechanism
Team behind work say this is a reminder that even simple reactions are more complicated than they first seem
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ResearchClick chemistry toolbox expanded with 'forbidden' C–C bond forming reaction
Copper-catalysed addition produces functional links that should be compatible with biological systems
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ResearchVersatile skeletal editing strategies upgrade nitrogen compounds into drug building blocks
Two techniques could help speed up the discovery of drugs containing nitrogen heterocycles
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ResearchSilver bullet catalyst works magic transforming stable C–H bonds into amines
Method allows for late-stage, stereoselective aminations to drug-like molecules
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ResearchMOF magnet with virtually no external magnetic field ideal for advanced electronics
Researchers say that the material could be used in spintronic devices
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ResearchFirst total synthesis of macrocycle with four stereocentres at the heart of bacterial photosynthesis
Technically daunting synthesis of bacteriochlorophyll a finally reaches completion
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Business‘Basic research is needed more than anything else’
Christian Hackenberger, co-founder of Tubulis, is excited that his team’s initial research is now creating clinical impact
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ResearchContra-thermodynamic stereochemical editing explained
How chemists are using light, enzymes and mechanical force to access higher‑energy stereoisomers without rebuilding a molecule from scratch
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ResearchUsing light to push stereochemistry uphill
While chemistry usually follows the downhill pull of thermodynamics, Alison Wendlandt is creating higher‑energy stereoisomers in the final stages of synthesis
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CareersSustainable laboratories: Cleaner solvents and substrates
How to identify greener replacements for DMF and recover ITO from glass substrates
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ResearchElectrochemistry unleashes untapped potential of strained rings to build molecules
One pot technique achieved functionalisation at up to four sites
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NewsChina dominates the discovery of new chemicals and reactions
The country’s contribution to known chemical space has grown exponentially in recent decades, driven by strong domestic R&D investment
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NewsExplosive growth in metal–organic framework research is concentrated in China
China contributes about 59% of global MOF publications, with the US in second place and the UK towards the bottom, analysis finds
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BusinessBoron plays a key role in new sleeping sickness drug
Acoziborole is the first single-dose treatment for both early and late stage sleeping sickness
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ResearchBreaking bonds and bringing disciplines together to replace one of chemistry’s most controversial molecules
Rebecca Trager meets an organic chemist catalysing the search for BPA replacements by connecting synthetic chemists, data scientists, toxicologists and polymer chemists
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OpinionTraffic jams in the chemical plant
What happens between a big order coming in and going out?
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ResearchElusive ‘dark matter’ diazo compounds captured from a human lung pathogen
Discovery might lead to simpler, safer ways to make diazo-based reagents