All Organic chemistry articles
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WebinarRobots in the lab – learn how automation can streamline your workflow
The future of lab automation is promising. Join us on 27 February to find out answers to the most important questions, and to contribute your knowledge and experience to the discussion.
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Research
Streamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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Research
Photochemistry frees arene functionalisation from metals
Sulfonium salts offer new possibilities for the alkylation and cyanation of aromatic molecules
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Research
Mechanochemistry set to expand availability of organomanganese reagents
Ball milling method avoids problems surrounding solution-based chemistry when synthesising arylmanganese nucleophiles
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Research
Benchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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Research
Manganese complex behind method for preparing silanols that uses water as an oxidant
By using water as an oxidising agent, the reaction eliminates additional reagents and unwanted side-products
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Feature
Fashion to dye for
Can colouring clothing be environmentally sustainable? Victoria Atkinson looks at how dyes have come full circle from their natural origins
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Research
Coca plants’ production pathway for cocaine finally unravelled
167-year-old biosynthetic mystery may be solved
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Opinion
Embracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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Research
Mystery surrounding metalation reaction’s reagent excess solved
Multiple ‘base-eating’ aggregates discovered in classic directed ortho lithiation
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Research
Quantum chemical analysis uncovers previously overlooked contributor to carbocation stability trend
Introducing substituents destabilises the parent substrates
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Research
Gigantic database of building blocks will help artificial intelligence uncover new organocatalysts
Publicly available dataset containing thousands of structures could help chemists develop data-driven reaction optimisation methods for organic synthesis
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Research
Fully automated synthesis robot sets new record in stereospecific carbon–carbon bond formation
The robotic platform can make six carbon–carbon bonds without human guidance
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Research
Chirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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Research
Controversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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Research
AI discovers the best general conditions yet for cross couplings, doubling yields
Algorithm works with robotic experimenter on tricky Suzuki–Miyaura reactions
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Feature
When will molecular electronics make the connection?
Computer chips based on single molecules may remain a work in progress, finds James Mitchell Crow but the technologies developed along the way are being used by chemists to explore their reactions
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Feature
How click conquered chemistry
Katrina Krämer tells the story of how click and bioorthogonal chemistry came to win the 2022 Nobel prize
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