All Medicinal chemistry articles
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BusinessThe diabetes drugs aiming to aid weight loss
Can peptide hormone mimics avoid the side effect pitfalls of previous weight loss treatments?
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Business
US supreme court confirms Amgen’s cholesterol antibody patents invalid
Decision could mean patent descriptions need to be even more detailed, and hence expensive
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News
Overlooked documents shed new light on double helix discovery
Rosalind Franklin was more than just a ‘wronged heroine’
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Business
Merck & Co to buy immunology specialist Prometheus
$10.8 billion cash deal give Merck rights to late-stage candidate for two inflammatory bowel conditions
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Business
Ghana and Nigeria approve Oxford malaria vaccine
Approval comes before final-stage clinical trials have been completed
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News
Air jet gun delivers needle-free vaccines in MOFs without any need for refrigeration
Release rate of injector system can be fine-tuned by changing the carrier gas
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Business
Pfizer to buy cancer biotech Seagen for $43 billion
Antibody-drug conjugate specialist will fill Pfizer’s cancer pipeline
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Research
Study challenges assumptions over how l-oligonucleotides behave in living systems
L-oligonucleotides are potentially cytotoxic but some could have unexpected therapeutic benefits
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Research
Peptide tags that encode chemical libraries could revolutionise drug discovery
Simple strings of amino acids store over 4 gigabits of data, offering a highly stable solution for screening small molecule libraries
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Research
The hunt is on for vaccine ingredients that don’t come from wild sharks
Yeast can provide the raw materials and chemical wizardry can transform them
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Research
Lipophilicity helps explain psychedelic drugs’ therapeutic effects
Understanding why psychedelic drugs that bind to serotonin receptors promote neuron growth, while serotonin itself does not
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Research
AlphaFold works with other AI tools to go from target to hit molecule in 30 days
End-to-end AI drug discovery process predicts potential inhibitors for a protein implicated in liver cancer
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Business
Encoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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Opinion
A decade on Crispr is already poised to deliver on its promise
Gene editing could transform healthcare but no disease should be forgotten
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Research
Molecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
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Opinion
Setting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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Research
Benchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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News
Crispr moves into the clinic
A mere decade after its discovery Crispr is already in clinical trials for everything from sickle cell disease to HIV and cancer
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News
Europe’s largest, hi-tech life sciences building is planned for UK
With lab space in the UK in short supply, a British property firm and Dutch real estate developer are building a massive vertical campus in London
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Research
Universal flu vaccine could head off future pandemics
More effective mRNA-based vaccine offers hope of ending annual flu shots for at risk groups
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