All Medicinal chemistry articles
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Business
Oxford–AstraZeneca vaccine joins others with promising interim data
Cheap and fridge-stable candidate at least 60% and up to 90% effective at preventing disease
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Business
Regulatory panel unconvinced by Alzheimer’s antibody evidence
US FDA advisors vote against approving Biogen’s aducanumab on the basis of incomplete data analysis
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Business
Moderna and Pfizer’s Covid-19 vaccines add more encouraging data
Pfizer–BioNTech reach safety threshold for emergency authorisation, while Moderna’s data peek suggests 95% efficacy
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Opinion
The ins and outs of vaccine trials
Derek Lowe lays out how the trials work, and why they get paused and restarted
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Opinion
A promising peep at Covid-19 vaccine efficacy
Pfizer–BioNTech’s will need to be one of many if we are to overcome the pandemic
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Business
Early indications suggest Pfizer–BioNTech’s Covid-19 vaccine is effective
Company claims 90% efficacy at preventing disease, but experts call for data rather than press releases
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News
Pandemic risks lost generation of junior scientists as charitable funding dries-up
Survey finds coronavirus, Brexit and lack of opportunities is forcing early career researchers backed by medical charities to consider alternative professions
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Podcast
Glycyrrhizic acid
A sweet treat with a deadly trick for Halloween – glycyrrhizic acid is found in black liquorice and sweeter than sucrose, but can cause heart problems and even prove fatal if consumed in excess
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Research
Fast-acting insecticide polymorph could boost malaria-control efforts
Recrystallised deltamethrin accelerates uptake in mosquitoes
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News
First Covid-19 challenge study working with live virus planned for the UK
Pending ethics panel approval, healthy volunteers would be infected with Sars-CoV-2 to help understand disease and test vaccines
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Research
Salt bridge strategy expands access to pharmaceutical cocrystals
New approach to cocrystallisation could lead to exciting multi-drug combinations
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Podcast
Bedaquiline
The first TB drug approved in 40 years gave hope to sufferers of drug resistant tuberculosis and ushered in a new class of antibiotics
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Opinion
Blood offering
Antibodies in various forms could bridge the Covid-19 treatment gap until a vaccine is available
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Opinion
Jumping the vaccine queue
Deals between companies and rich governments offset manufacturing risks, but must not compromise supplies to those in need
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Business
Covid-19 vaccine deals risk skewing supply
International accords including Covax aiming to ensure equitable distribution to poorer countries
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Business
Protein-based Covid-19 vaccines could overshadow rivals
Although slower to develop, protein-based vaccines are well understood with a strong record of safety and effectiveness
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Research
DNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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News
Rush to approve Covid vaccine prompted by politics may end in disaster
Push by governments to pass a vaccine without appropriate evidence could damage fight against virus
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Opinion
Facing the challenge of vaccine trials
Russia’s Covid-19 gamble is a stark contrast to even accelerated clinical programmes
