All Medicinal chemistry articles
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ResearchSynthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
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Business
Revived Alzheimer’s antibody met with guarded optimism
Biogen’s aducanumab offers the possibility to slow disease progress, but regulators will likely want more convincing evidence
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Research
Compact pharmaceutical factory manufactures drugs on demand
Plant with modular design would occupy about half the area of a squash court
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Research
Inorganic fragment library ready to help drug discoverers reach neglected regions of chemical space
A new approach to fragment-based drug design
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Podcast
Iminosugars
After some promising results treating ill pets, some researchers think iminosugars could become treatments for infection and even cancer. Mike Freemantle explores the buzz around iminohoney
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Business
Pharmaceuticals roundup 2019
Under the shadow of political turmoil and major lawsuits, the industry returned to its strengths – making new drugs, and finding new ways to do it better
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Research
Engineered insulin with enhanced thermal stability inspired by fish-hunting snails
Four-disulfide insulin has similar bioactivity to native human insulin
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News
European commission gives green light to first Ebola vaccine
Drug shown to be effective and safe following clinical trials involving 16,000 people
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Research
Flow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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Opinion
Will computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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News
Study claiming gene-edited babies were more likely to die young was wrong
Database bias introduced major error in a now retracted study on Crispr babies’ mortality
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Podcast
Hypoxia-inducible factors – HIFs
The oxygen sensors that help life react to changing conditions, key to the 2019 Nobel prize in physiology or medicine
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Business
The rise of venture philanthropy
More and more charities are investing in companies, and looking for returns on that investment, as an alternative to traditional grants
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Sponsored
The future of chemistry: Science Horizons and Chemistry Means Business
Hundreds of scientists contributed to the Royal Society of Chemistry’s Science Horizons report to build a picture of the challenges and opportunities the next generation will bring
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Research
Alzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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Research
Metallohelices emulate antimicrobial peptides
Scientists move away from traditional drug candidates to evade resistance
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Business
Sixth in a line of Alzheimer’s drugs fails in trials
Treatments designed to stop amyloid peptide formation all seem to cause cognitive impairment rather than prevent it
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Sponsored
The importance of solid form science in modern drug development
A recent study suggests that around 40% of drugs with market approval exhibit poor water solubility and although this is not a new problem, solutions like those offered by Johnson Matthey are still relevant to today’s pharma market
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Research
Elusive protein and key to many tropical diseases found after decades of searching
Discovery offers powerful new target to treat trypanosome parasite illnesses that affect millions
