Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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Business23 Indian children’s deaths linked to contaminated cough syrup
Dietheylene glycol contamination highlights consequences of poor inspection and enforcement
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ResearchUltrapotent thrombin inhibitor combines peptide fragments from a trio of blood-sucking organisms
Hybrid molecule featuring leech, tsetse fly and flea peptide fragments binds thrombin at three sites
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WebinarDeveloping a CITK protein degrader using the QuicTPD™ platform
Join us on 18 November to learn about the latest technology to accelerate the design of cancer treatments
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OpinionKeeping tabs on contamination
Argentina’s contaminated fentanyl tragedy highlights challenges of generic drug supply
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BusinessArvinas and Pfizer seek a new home for protein degrader drug
Companies offer bifunctional cancer drug vepdegestrant to new partners after disappointing trial results
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BusinessNovo Nordisk’s new chief cuts 9000 jobs
Danish firm shifts strategy after struggling to capitalise on its weight loss drugs
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ResearchGut bacterium amplifies amphetamine’s addictive pull
Discovery could lead to better ways to treat addiction
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OpinionIs UK pharma really ‘uninvestable’?
Merck & Co, AstraZeneca (AZ) and Eli Lilly pulling UK projects highlights the precarious position of the country’s life sciences industry
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BusinessUK loses life sciences investment as pharma companies halt expansion plans
Industry seeks greater share of healthcare spending to support innovation
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WebinarIon suppression correction and normalisation in metabolomics
Join us on 5 November to learn new ways to improve data consistency with mass spectrometry
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OpinionLiver toxicity remains an unpredictable hurdle for medicinal chemists
The liver’s complex role in metabolising drugs makes it both a critical consideration and potential stumbling block
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OpinionDeadly fentanyl contamination exposes drug safety challenges
Bacterial contamination in medical fentanyl has killed at least 51 people in Argentina, highlighting pressures on generic drugmakers
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WebinarLipidomics for antibiotic resistance (AMR) mechanisms
Join us on 23 October to discover how microbial antibiotic exposure triggers lipidomic changes, offering insight into how lipids contribute to resistance mechanisms
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ResearchScientists capture crystal structures of cannabinoid receptor in action
Study reveals how two aromatic residues flip when agonists bind, providing the trigger for downstream signalling
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CareersTeaching the next generation of cosmetic scientists
Trailblazing course receives accreditation from the Royal Society of Chemistry
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OpinionThe clean beauty movement highlights wider challenges in balancing chemical risks and benefits
The ‘clean beauty’ movement exemplifies broader challenges in how we evaluate chemical safety, balancing risks against benefits while avoiding regrettable substitutions.
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OpinionThe conceptual challenge of consumer safety
Understanding causation can motivate product improvements
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FeatureConsumers question safety of parabens and PFAS in personal care products amid health concerns
Growing research into cosmetic ingredients has been raising safety concerns among consumers. Bárbara Pinho explores the future of safer chemistry amid the ‘clean beauty’ trend
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ResearchNew class of antifungals show potent effects against priority pathogens
Coniotins, found in another fungus, is effective against drug-resistant pathogenic fungi
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ResearchAntibiotics designed with the help of AI attack bacteria in entirely new ways
Two new compounds display potent activity against deadly drug-resistant bacteria