Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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BusinessAntibody data manipulation extends to thousands of images across 15 suppliers
Sleuths discover widespread, systematic alteration of Western blots and other antibody data
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PodcastAdvances in CAR-T cancer therapy & carbon materials’ hidden defects
What does recent success with bladder tumours mean for solid cancer treatment? And we discuss why scientists are rethinking how they assign peaks in spectra of carbon-based materials.
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ResearchBenchmark flaws may be distorting AI drug-discovery leaderboards
Audit identifies subtle but consequential issues, such as conflicting labels and train–test leakage, in numerous benchmark datasets
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BusinessProtein degrader approval offers hope to relapsed multiple myeloma patients
Highly potent molecular glue drug iberdomide doubles the number of patients reaching fewer than one myeloma cell per 100,000 in bone marrow
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FeatureCracking the ubiquitin code to unlock new drug targets
The approval of the first Protac cancer drug marks a turning point in medicine – but scientists are only beginning to decode the complex molecular language that makes it possible
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OpinionChemistry contains multitudes
There’s room (and need) for all the various subspecies of chemical scientists
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ResearchOrganocatalyst streamlines oligonucleotide drug synthesis
New reaction controls phosphorus stereochemistry during the synthesis of phosphorothioate oligonucleotides
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OpinionArtificial intelligence or clever artifice?
It’s important to be realistic about what AI can, and can’t, achieve, across the chemistry enterprise
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BusinessPfizer’s green chemistry team turns 25
What began as a grassroots initiative has become embedded across Pfizer’s research and manufacturing operations, helping reshape processes from Viagra to Paxlovid
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ResearchCovalent drugs just got a new ‘spring-loaded’ warhead
Sulfur(IV) reagent allows late-stage installation of bicyclobutanes to drug molecules, expanding a limited tool box
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BusinessOral cholesterol-lowering peptide approved after a decade in development
Merck & Co’s Lipfendra (enlicitide) employs 13 enzymes in biocatalytic synthesis
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ResearchRe-engineered psychedelic drug retains therapeutic activity in mice, while limiting negative side effects
Rationally designed molecular structure targets a specific subset of serotonin receptors, and potentially offers a route towards safer psychedelic treatments
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BusinessIndia’s generic GLP-1 drugs are (mostly) booming
Manufacturing problems for some manufacturers have led to production pauses and recalled batches of diabetes and weight loss drugs
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Podcast50 years after Seveso & changing the way we separate hydrocarbons
What have we learned 50 years on from the Seveso accident? And we discuss three promising membrane strategies that could replace fractional distillation in crude oil refineries.
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WebinarOne goal, three industries: retrosynthesis for pharma, agrochemicals and flavours & fragrances
Join us on 15 September as we explore the latest in AI-powered retrosynthetic software, evaluating its performance across three different industries
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BusinessRegulators push Amgen to withdraw drug due to data manipulation
Questions raised over safety and efficacy of Tavneos (avacopan)
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BusinessRewriting genetic medicine
Scribe Therapeutics will soon begin clinical trials for its epigenetic treatment to tackle ‘bad’ cholesterol
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ResearchMetabolised antibiotics can drive antimicrobial resistance just as much as their parent compounds
Studies on wastewater show that antibiotic transformation products may play an underappreciated role in driving antimicrobial resistance
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ResearchClever chemistry turns antibiotic-resistant bacteria’s own defences against them
Photosensitiser is activated by enzyme linked to resistance, making bacteria vulnerable to light therapy
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OpinionWhat kinds of reactions do you do most?
Variety may be the spice of life, but there’s space for the boring but effective