All Medicinal chemistry articles
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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News
Race to understand Sars-CoV-2 variants amid fears virus might evade vaccines
Biochemical basis behind coronavirus variants’ success could hold key to defeating them
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Business
BMS and Eisai agree antibody-drug conjugate commercialisation deal
Companies will jointly develop cancer treatment, with BMS paying up to $3 billion for shared rights
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Feature
Supermetals versus superbugs
With pathogenic bacteria rapidly overcoming our arsenal of organic antibiotics, James Mitchell Crow asks if it is time to revisit metal-based antimicrobials
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Business
Regeneron’s Covid-19 antibodies help those who can’t make their own
Regn-Cov2 reduces deaths and shortens hospitalisation for these patients, even when given at late stages of infection
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Research
Blocking bacteria’s self-poisoning mechanism weakens their antibiotic resistance
Stopping bacteria from producing hydrogen sulfide in response to drugs could help overcome antimicrobial resistance
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Business
Alzheimer’s antibody gets surprise US approval
Good news for industry and future drug approvals, but physicians doubt it will be effective for most patients
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Research
Protein impurities found in AstraZeneca’s Covid-19 vaccine stir debate
Compounds might cause side effects but are unlikely to be behind extremely rare blood-clotting events
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Research
Synthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
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Business
Morphosys agrees to buy cancer epigenetics specialist Constellation
$1.7bn deal will be funded by selling rights to royalties on existing drugs
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Business
Striving to bolster the antibiotic pipeline before it becomes the next crisis
It’s been almost 10 years since the world was warned of a post-antibiotic apocalypse. Katrina Megget takes a look at the initiatives trying to support antimicrobial R&D
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Research
Click chemistry uses endogenous acrolein to activate cancer prodrug
Strategy could reduce chemotherapy side effects by selecting for cancerous cells
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Research
Tri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core
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Webinar
Molecular modeling for the medicinal chemistry toolkit
Join us to discover how to streamline your workflows using integrated software solutions for docking, ligand design, and optimisation
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Research
Ingestible COF that delivers insulin could help diabetics duck injections
When blood glucose levels are high, glucose displaces insulin loaded in the framework
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Research
Machine learning tool sets out to find new antimicrobial peptides
IBM researchers say their fully automated AI-driven system could speed up the discovery of molecules for novel antibiotics
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Sponsored
Digital technologies in the personalised medicines revolution
The revolution will be digitalised
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Sponsored
Unlocking the future of medicines manufacturing with digital innovations
The Medicines Manufacturing Innovation Centre promises to revolutionise how we formulate, trial and produce medicines
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Business
Antibody–drug conjugates drive growth in oncology
Antibody–drug conjugates are coming of age and pharma is investing, reports Katrina Megget
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Feature
Flow chemistry surges forward
The long-discussed technique could help make pharma manufacturing more distributed, finds Andy Extance, and create opportunities for chemists with the right skills
