Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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WhitepaperOptimise drug discovery: predicting transporter-mediated drug interactions
Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies
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ResearchGraphene-enhanced supramolecular gels direct how drug molecules crystallise
System could be useful in preformulation stage of drug development
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ResearchCascade reaction brings a new dimension to amine synthesis
Method creates two new rings and four new bonds
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ResearchSimple blood test could enable detection of Parkinson’s disease before symptoms emerge
Test on tRNA fragment ratios shows promise
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NewsFears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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BusinessAcceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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ResearchRare disease drug can make human blood toxic to mosquitoes
Insect enzyme inhibitor could help control malaria
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BusinessEpigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code
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BusinessUS regulatory chief’s resignation raises alarms in biotech industry
FDA vaccines and biologicals centre director, Peter Marks, clashed with health secretary Robert F Kennedy Jr
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OpinionWelcome to the MegaPharm target selection and project resourcing meeting
Overheard recently in a seminar room near you…
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OpinionWeight loss drug supply races
With official shortages ended, but the first generics gearing up for launch, companies are looking for the next generation of drugs
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
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BusinessEnding of US weight-loss drug shortages prompts compounder complaints
Decision ends pharmacies’ permission to prepare versions of GLP-1 hormone mimics
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OpinionFluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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ResearchGenerative AI pipeline creates promising antimicrobial peptides
AI model extrapolates beyond training data to predict diverse antimicrobial structures
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OpinionHow natural nanomotors could propel new drug delivery systems
Biological cells including bacteria, sperm cells and microalgae show promise for precision treatments
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BusinessNew type of painkiller approved in US
Sodium channel blocker prevents nerves transmitting pain signals
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FeaturePutting the F in pharma
Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element
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ResearchFar more drugs could be taken orally by formulating them with silica nanoparticles
Many more medicines could be made water soluble making taking them easier for patients
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ResearchMapping metabolite disturbances by drugs
High-throughput metabolomic profiling gives insight into unpredictable drug effects