Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchDNA barcodes can make drug discovery screens miss potential medicines
Flawed data is likely compromising machine learning methods
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BusinessUS approves twice yearly injection to prevent HIV
Yeztugo (lenacapavir) provided near-total protection against infection in clinical trials
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FeatureHibernation awakens interest for drug discovery
With many different species entering torpor for a variety of reasons, scientists are looking to their sleepy secrets for ways to treat human diseases. Anthony King reports
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BusinessSanofi to buy Blueprint Medicines for over $9 billion
Blueprint has one approved drug and enhances Sanofi’s immunology portfolio
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OpinionNon-hallucinogenic psychedelics
Chemical insights and advances are contributing to a new therapeutic avenue for mental health conditions
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ResearchAFM maps the way collagen unfolds and refolds in the body
New insights could aid understanding of connective tissue disorders
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ResearchSelective C–H bond fluorination enables conformational reporting in a complex natural product
Radical fluorination leaves extant functional groups intact
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ResearchNanocomplex becomes a master of shape-shifting to target tumour cells
Switching from nanofibres in the blood to virus-like particles in a tumour environment brings drugs to where they are needed
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OpinionIgnoring women’s health shouldn’t be an option
Developing therapies for conditions that predominantly affect women is a neglected, but enormous, opportunity
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WebinarModelling amorphous solid dispersion (ASD) release mechanisms
Learn how thermodynamic modelling and molecular simulation can help our understanding of amorphous solid dispersion
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FeatureFixing medicine’s gender gap
For centuries, the default subject in medicine research and training has been the male. Julia Robinson talks to the scientists and clinicians trying to improve things for the other 51% of humanity
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FeatureManaging the menopause
The end of ovulation will affect almost all women, but current treatments could be improved. Rachel Brazil reports on the efforts to find a better solution
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FeatureHow safe and sustainable are period products?
Millions of people around the world use period products every month. Bárbara Pinho finds out what their environmental footprint is and whether they carry chemicals harmful to human health
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OpinionThe women-led health projects doing things differently
Innovative approaches to awareness and participation
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CareersHow Bathabile Ramalapa is making a place for chemistry in health innovation
The award-winning scientist is solving health problems in the global south and inspiring other girls to follow suit
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OpinionWomen are not just another confounding factor in drug development
Ignoring physiological differences between the sexes is indefensible
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Research3D printing deep in the body using ultrasound could deliver drugs, heal wounds
Biocompatible inks allowed polymers to be printed in animals without harming them
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ResearchGlycoconjugate-caged drugs offer better way to treat inflammatory bowel disease
Plant fibres trap drugs, only releasing them in the lower intestine where they are more effective
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ResearchAccelerating chemical discovery through high-throughput experimentation: in conversation with Matthew Gaunt
Professor Matthew Gaunt from the University of Cambridge shares his thoughts on HTE and the role of automation and computational models in discovering new chemical space.
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OpinionIn search of truth and rules
To codify and predict ever more complex phenomena is one of science’s great drivers