Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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FeatureFixing medicine’s gender gap
For centuries, the default subject in medicine research and training has been the male. Julia Robinson talks to the scientists and clinicians trying to improve things for the other 51% of humanity
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FeatureManaging the menopause
The end of ovulation will affect almost all women, but current treatments could be improved. Rachel Brazil reports on the efforts to find a better solution
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FeatureHow safe and sustainable are period products?
Millions of people around the world use period products every month. Bárbara Pinho finds out what their environmental footprint is and whether they carry chemicals harmful to human health
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OpinionThe women-led health projects doing things differently
Innovative approaches to awareness and participation
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CareersHow Bathabile Ramalapa is making a place for chemistry in health innovation
The award-winning scientist is solving health problems in the global south and inspiring other girls to follow suit
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OpinionWomen are not just another confounding factor in drug development
Ignoring physiological differences between the sexes is indefensible
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Research3D printing deep in the body using ultrasound could deliver drugs, heal wounds
Biocompatible inks allowed polymers to be printed in animals without harming them
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ResearchGlycoconjugate-caged drugs offer better way to treat inflammatory bowel disease
Plant fibres trap drugs, only releasing them in the lower intestine where they are more effective
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ResearchAccelerating chemical discovery through high-throughput experimentation: in conversation with Matthew Gaunt
Professor Matthew Gaunt from the University of Cambridge shares his thoughts on HTE and the role of automation and computational models in discovering new chemical space.
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OpinionIn search of truth and rules
To codify and predict ever more complex phenomena is one of science’s great drivers
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BusinessMerck KGaA to buy cancer specialist SpringWorks
$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries
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ResearchLSD analogue synthesised by swapping just two atoms less likely to cause hallucinations
New molecule shows promise for treating neuropsychiatric conditions such as schizophrenia
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WhitepaperOptimise drug discovery: predicting transporter-mediated drug interactions
Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies
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ResearchGraphene-enhanced supramolecular gels direct how drug molecules crystallise
System could be useful in preformulation stage of drug development
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ResearchCascade reaction brings a new dimension to amine synthesis
Method creates two new rings and four new bonds
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ResearchSimple blood test could enable detection of Parkinson’s disease before symptoms emerge
Test on tRNA fragment ratios shows promise
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NewsFears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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BusinessAcceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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ResearchRare disease drug can make human blood toxic to mosquitoes
Insect enzyme inhibitor could help control malaria
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BusinessEpigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code