Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
-
ResearchCrystal structure prediction reaches new heights with axitinib
Computational strategy predicts complex polymorphs and distinguishes salts from co-crystals
-
BusinessUK agrees higher drug prices to secure zero-tariff deal with US
NHS could pay up to 25% more for innovative drugs, but exports will be tariff free for three years
-
OpinionWhat’s on your lab technology wish list?
Once-magical tools are now mundane. What will the next miracles be?
-
ResearchRevived claims that antibiotics don’t kill bacteria with reactive oxygen prove controversial
Researchers say that multiple lines of evidence for hypothesis have now been undermined
-
OpinionInhaler propellant switch is worth the effort
Memories of a year spent testing new inhaler valve designs
-
NewsCould Crispr cure HIV?
The first gene-editing therapies for HIV/Aids are entering trials but the virus is proving once again that it is a master at evading eradication
-
ResearchCharge-switching polymer could hold the key to needle-free insulin gel
Animal tests reveal zwitterionic polymer can transport insulin through skin and regulate blood glucose
-
OpinionA robotic helping hand
Mechanical labmates are making huge progress, but there are still big challenges to overcome
-
ResearchCryo-EM snapshots reveal insight into how opioids activate their receptor
Insights from structural images could help design new opioids and antidotes to them
-
FeatureOne medical inhaler can have the impact of 30kg of carbon dioxide
Propellants in asthma inhalers produce greenhouse gas emissions equivalent to driving 200 miles, yet most healthcare systems overlook this climate impact. New low-carbon alternatives are in development, Andy Extance reports, but barriers remain
-
ResearchAI-designed antibodies target antigens with atomic precision
Epitope-binding proteins designed from scratch by generative AI model
-
ResearchAI cut development time of antibiotic that spares gut-friendly bacteria by two years
Animal tests show promise to target invasive strain of E. coli but approval for use in humans is still years away
-
BusinessPfizer and Novo Nordisk’s battle over Metsera
Lawsuits fly in bidding war over developer of next generation weight loss drugs
-
ResearchNanobodies from alpacas and llamas could hold the key to a universal antivenom
Novel nanobody mix protects against 17 African snake species
-
BusinessNovartis spends on deals to offset patent losses
$12 billion Avidity acquisition is the latest pipeline-pumping transaction
-
ResearchThis fragment-based drug discovery library is designed to be sociable
Study targets a key bottleneck in hit to lead optimisation by designing fragments that are both structurally diverse and easy to elaborate
-
WebinarSYNTHIA for chemists: faster route design
Join us on 11 December to discover how SYNTHIA accelerates retrosynthesis by helping chemists design, compare and refine routes with customisable filters and commercial building blocks
-
Business23 Indian children’s deaths linked to contaminated cough syrup
Dietheylene glycol contamination highlights consequences of poor inspection and enforcement
-
ResearchUltrapotent thrombin inhibitor combines peptide fragments from a trio of blood-sucking organisms
Hybrid molecule featuring leech, tsetse fly and flea peptide fragments binds thrombin at three sites
-
WebinarDeveloping a CITK protein degrader using the QuicTPD™ platform
Learn about the latest technology to accelerate the design of cancer treatments