All Medicinal chemistry articles
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ResearchFlow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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Opinion
Will computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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News
Study claiming gene-edited babies were more likely to die young was wrong
Database bias introduced major error in a now retracted study on Crispr babies’ mortality
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Podcast
Hypoxia-inducible factors – HIFs
The oxygen sensors that help life react to changing conditions, key to the 2019 Nobel prize in physiology or medicine
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Business
The rise of venture philanthropy
More and more charities are investing in companies, and looking for returns on that investment, as an alternative to traditional grants
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Sponsored
The future of chemistry: Science Horizons and Chemistry Means Business
Hundreds of scientists contributed to the Royal Society of Chemistry’s Science Horizons report to build a picture of the challenges and opportunities the next generation will bring
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Research
Alzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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Research
Metallohelices emulate antimicrobial peptides
Scientists move away from traditional drug candidates to evade resistance
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Business
Sixth in a line of Alzheimer’s drugs fails in trials
Treatments designed to stop amyloid peptide formation all seem to cause cognitive impairment rather than prevent it
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Sponsored
The importance of solid form science in modern drug development
A recent study suggests that around 40% of drugs with market approval exhibit poor water solubility and although this is not a new problem, solutions like those offered by Johnson Matthey are still relevant to today’s pharma market
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Research
Elusive protein and key to many tropical diseases found after decades of searching
Discovery offers powerful new target to treat trypanosome parasite illnesses that affect millions
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News
US children’s hospital takes delivery of one of world’s most powerful NMR spectrometers
Instrument offers unprecedented opportunities to study disease development
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Review
Mescaline: A Global History of the First Psychedelic
A story about the people who harvested, used, abused, regulated and investigated the mind-altering drug
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Feature
Stem cell hype
Many clinics around the world offer unproven treatments, while genuine therapies are slowly making their way through trials. Anthony King reports
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Podcast
Boric acid
Mike Freemantle revisits battlefield surgery to investigate boric acid, a key part of Dakin's antiseptic solution used extensively in the first world war
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Research
Retrosynthetic algorithm broadened to design similar, but different, molecules
Chematica can now design efficient syntheses for large compound libraries
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Podcast
Amygdalin & Laetrile
Patrick Hughes delves into the molecule at the centre of a decades-old cancer treatment conspiracy theory
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News
Data manipulation casts shadows on Novartis gene therapy
Manufacturing problems with other new medicines highlight difficulty of developing advanced treatments
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Opinion
Margaret Brimble: 'Spiroketals are my favourite molecules'
The New Zealand chemist on careers, creativity and why everything just has to be blue
