All Medicinal chemistry articles
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BusinessAlzheimer’s antibody engenders anticipation
Tantalising press-released data on Biogen and Eisai’s lecanemab prompt questions without firm answers
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Business
An evolution in pharma outsourcing
Contract services firms are becoming increasingly sophisticated and embedded in the ecosystem of drug development
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Opinion
Contribute to defeating malaria
The Medicines for Malaria Venture needs new compounds for screening and more chemists to join its open-souce drug discovery project
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Research
Yeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
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Opinion
Confusing cannabinoids
Decomposition during GC–MS analysis can thwart efforts to determine if a product is legal
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Webinar
Finding new medicines for malaria
Join Chemistry World for this interactive webinar and explore some of the collaborative avenues of research looking for new medicines to prevent and treat one of our oldest foes.
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Research
Combining expertise to develop remote-controlled nanomaterials
Beatriz Pelaz explains how her research tackles bionanomaterials from multiple angles
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Business
Protective treatment for Covid-19 makes minimal impact
Limited uptake of antibody combination for vulnerable patients, while demand for antivirals seems to be slowing
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Opinion
Why AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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News
Software from Cambridge crystallographic experts could save pharma industry millions
Informatic tools will help drug formulators understand particle behaviour in their final product
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Opinion
May cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated
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Research
Antigen-carrying adjuvants activate both adaptive and innate immunity
Aluminosilicate nanoparticles promote ion perturbation, pyroptosis and enhanced immunity in a cancer model
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Business
California advances plans to make its own insulin
Governor commits $100 million to develop low-cost insulin and build manufacturing facility to strengthen drug’s supply chain
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Opinion
Alzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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News
New questions raised over Sputnik Covid vaccine results point to fraudulent practices
Analysis comparing Sputnik results with five other Covid vaccines finds phase 3 trial outcome is highly improbable
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Feature
Using genetics to personalise prescriptions
We’ve known for a long time that different people respond to certain drugs to very different extents, but now cheap DNA testing could make these disparities a thing of the past, as Ian Le Guillou reports
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Research
Light-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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Research
Breaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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Business
What is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
