All Medicinal chemistry articles
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BusinessProtein-based Covid-19 vaccines could overshadow rivals
Although slower to develop, protein-based vaccines are well understood with a strong record of safety and effectiveness
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Sponsored
DNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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News
Rush to approve Covid vaccine prompted by politics may end in disaster
Push by governments to pass a vaccine without appropriate evidence could damage fight against virus
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Opinion
Facing the challenge of vaccine trials
Russia’s Covid-19 gamble is a stark contrast to even accelerated clinical programmes
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Business
Russian vaccine launch shocks scientists
Sputnik V to be approved without large human trial data
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Business
Encouraging signs from initial Covid-19 vaccine trials
Human trials deliver positive immune responses, while primate challenge studies suggest protection is possible
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Feature
Why is cystic fibrosis so hard to treat?
Claire Jarvis talks to the scientists trying to find new drugs to treat the inherited lung condition
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Research
Translating snail venom research from beach to bench and beyond
Meet Mandë Holford, an interdisciplinary scientist following tangents that arise when exploring the molecular-level workings of venom peptides
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Podcast
Favipiravir
Originally developed to treat flu and marketed in Japan as Avigan, promising Covid-19 trial results have seen countries stockpiling this medication by the millions
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Podcast
Tannic acid
Tannic acid in green acorns can kill wild animals and livestock, but you can prevent poisoning with pannage pigs
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Research
Common inactive drug ingredients not as inert as thought
38 out of 639 excipients tested interact with toxicity-related proteins, some reaching levels that might produce unwanted effects
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Opinion
Looking beyond the next wave
We need to apply lessons from Covid-19 to tackle antimicrobial resistance and climate change
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Business
What are the risks of fast-tracking a Covid-19 vaccine?
Condensing timelines from years to months inevitably involves compromises
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Opinion
Ghanaian biochemistry TV star Marian Addy
Marian Addy was the first female science professor in Ghana, who studied herbal medicine – and was a TV star
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Sponsored
Collaborative chemistry
Welcome to our collaborative chemistry collection, which shows collaborations creating a more connected tomorrow as challenges in science and industry increase
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Business
Scrambling and gambling to scale up Covid-19 medicines
Organisations work towards making billions of doses of products not yet proven to work
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Opinion
Dragons of immunology
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
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Research
Unprecedented biosynthetic transformation found to connect antibacterial polyketides from ant microbiome
Study identifies enzymes that convert flat fasamycins into three-dimensional formicamycins
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Research
Algorithm devises synthetic contingency plans for Covid-19 drug
Retrosynthesis software tool can identify multiple synthetic routes that use inexpensive and diverse starting materials while avoiding patented methods
