Physical chemistry – Page 10
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Opinion
Why AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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News
AlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe
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Research
Rich chemistry revealed by tip microscopy pulses’ bond making and breaking
Using an STM, scientists have been able to precisely switch between three different molecules, opening the way to multiple selective transformations
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Research
Improbable rotaxane made using a foldamer helix
Macrocycle displaced to a site for which it has no formal affinity
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Opinion
Lessons in meaning from surface science
Do the measurements we take in vacuum mean anything in real-life situations?
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Research
Theories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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Opinion
Callendar’s platinum thermometer
Solving the hot topic of accurate and reproducible temperature measurement
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Research
Perfectly planar stable silicon clusters with six contacts predicted
Hexacoordinated systems theorised to remain stable, even with protecting ligands
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Opinion
In search of the chemical bond
Philosophy of science can help us discover new ways of understanding whether bonds really exist
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Research
Electric fields bring new dimension to debate on atomic size
A new methodology gives surprising answers to an old question
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Research
Quantum nature of hydrogen bonds observed in acid–base complex
Spectroscopic evidence of proton delocalisation could change the way we approach acid–base chemistry
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Opinion
Letters: June 2022
Readers share poems and memories, and report a textbook theft by the man who stole Einstein’s brain
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Opinion
Carolyn Bertozzi: ‘Shooting hoops is very meditative’
The celebrated chemical biologist who dreamed of being a rock star before inventing the field of bioorthogonal chemistry
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Research
Magnetic fields generate intricate periodic trends
By including magnetic fields in conceptual DFT, scientists have been able to use it to predict chemical behaviour under extreme conditions
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Research
Rydberg atoms can form molecular bonds with charged species
Researchers observe unusual bond, which is substantially longer than classical covalent interactions
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News
Yield-predicting AI needs chemists to stop ignoring failed experiments
For machine-learning algorithms to make accurate yield predictions, chemists need to start reporting more low-yielding reactions and spell out implied experimental details
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Research
AI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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Research
AI tool finds green ways to turn chemical waste into drugs
Circular approach for industry by-products considers environmental, economic and geographic aspects to rank predicted routes for real-world applications
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Research
Strange new bonds found hiding in plain sight in common organometallics
Collective interactions are proof that there’s more to bonds than just connecting neighbouring atoms