All enzymes articles
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Research
Light-driven enzyme engineered and repurposed to catalyse unnatural reaction
Directed evolution used to create photoenzyme that can perform new-to-nature radical cyclisation
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Research
Unravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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Research
Chemical industry hasn’t yet developed an appetite for biocatalysis, survey finds
Misconceptions along with a lack of time and resources driving industry’s reluctant attitude to biocatalysis and chemoenzymatic catalysis
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Business
Recycling plastic with enzymes
Carbios can return even hard-to-recycle polyester fibres and textiles to their constituent monomers
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Feature
Fixing nitrogen fixing
Green ammonia promises a more sustainable future. Jamie Durrani talks to the researchers aiming to revolutionise the production of crucial fertiliser
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Research
NMR reveals sialic acid biosynthesis in real time
Using NMR, scientists can directly measure sialic acid enzyme conversion velocities for the first time
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Research
Unexpected autocatalytic effect gives light-driven enzyme a boost to synthesise green fuels
Discovery could enhance production of liquid fuels by algae
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Research
Diverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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Research
NMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
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Research
Designer catalyst with enzyme-like cavity splits water almost as fast as plants
Catalytic cleft offers new strategy to speed up hydrogen synthesis
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Research
Artificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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Research
Nature inspires greener generation of metal hydrides to make formic acid from CO2
The iron–sulfur cluster catalyses the electrocatalytic formation of manganese hydrides
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Research
Theories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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Research
Microdroplets tackle scale-up issues for enzyme-photocoupled catalysis
Gas-spray reactor enhances light illumination efficiency and boosts rate of reaction
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Research
AI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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Research
Yeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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Research
IBM teaches reaction planning system to ‘speak enzyme’
RXN seeks to use enzyme catalysis to make chemistry more sustainable and resource efficient
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Research
Electric field of ATP synthase suggests enzyme has functions beyond catalysis
Study links energy-making enzyme with proton migration in ATP formation, and reinforces predictions that its catalytic efficiency is around 90%
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Research
Engineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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Research
Evolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions