All articles by Andy Extance
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BusinessArvinas and Pfizer seek a new home for protein degrader drug
Companies offer bifunctional cancer drug vepdegestrant to new partners after disappointing trial results
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ResearchFirst valence electron measurements capture fleeting reaction process
Femtosecond timescale x-ray laser measurements study how a hydrogen atom breaks off an ammonia molecule
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BusinessSarepta gene therapy deaths highlight tragic rare disease dilemma
Regulators block Duchenne muscular dystrophy treatment after fatal side-effects outweigh questionable efficacy
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NewsExplainer: The chemistry of permastink and how to prevent it
How to avoid throwing out smelly polyester sportswear
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FeatureHow decarbonisation will help the UK’s last refineries survive
Carbon capture and low-carbon hydrogen are central to any possibility of supplying liquid fuels compatible with net zero, reports Andy Extance
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NewsWhat are the prospects for making green hydrogen straight from seawater?
Competing with better-established desalination coupled with electrolysis, direct seawater splitting technologies are targeting niches
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ResearchReprocess, reuse, repeat: greener recycling of perovskite solar cells cuts costs
Mainly water-based approach is also cheaper than using new starting materials
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FeatureThe promise of drugs that send proteins to the shredder
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery
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ResearchGPT-based AI tool predicts inorganic crystal structures
CrystaLLM uses GPT to arrange atoms, turning text-based data into numerical tokens
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FeatureA mouthful of mouthfeel
Andy Extance learns how the chemicals in food and drink create sensual culinary experiences
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ResearchVisible light-powered catalysts clean up ‘forever chemicals’
Organic photoredox catalysts show promise for fluorinated pollutants
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FeatureClearing up the compostable plastic mess
Rather than a potential triumph, the compostable plastics we use look increasingly like a tragedy. Andy Extance looks at the problems and seeks solutions
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ResearchProteins with multiple structures open up AlphaFold’s black box
AI prediction model often fails to identify fold-switching, helping show how it works and the limits of its usefulness
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FeatureHow satellite remote sensing is enhancing our understanding of Earth
Instruments in space have studied the planet’s atmosphere and surface, and are now being joined by powerful new ones, finds Andy Extance
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BusinessMDMA rejection poses questions for psychedelic drug trials
Decision prompts reflection over how psychotherapy is involved, regulating combination treatments and safeguarding patients
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ResearchAI tool outperforms existing x-ray structure methods
Deep learning approach determines phase of diffracted beams with lower-quality data
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ResearchThe catalyst speedup toolkit
A rundown of the various strategies scientists are exploring to cheat the Sabatier limit
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FeatureHow a new strategy aims to break the catalytic speed limit
The Sabatier principle normally defines the maximum reaction rate enabled by catalyst materials, but scientists now think that they can go even faster, explains Andy Extance
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NewsHow can your lab cut water use in reflux reactions?
Practical advice builds on a new study comparing air-cooled condensers
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FeatureBrain chemistry basics
Andy Extance looks into the latest in Alzheimer’s disease, pain and memory