Study challenges notion that solution-phase organic reactions are unfeasible at high temperatures

By Hannah Hamilton2025-03-07T12:48:00

Three thin glass tubes that have been sealed containing a pale yellow liquid

Source: © Valentine P Ananikov/Zelinsky Institute of Organic Chemistry

Capillary synthesis at 500°C converts N-substituted pyrazoles into their isomers within five minutes

Chemists have used sealed glass capillaries to perform pyrazole isomerisation reactions at temperatures as hot as 500°C. By demonstrating that capillary synthesis is a viable way to perform solution-phase reactions at high temperatures, the researchers behind the work say they hope to use their method to unlock entirely new synthetic pathways and significantly simplify the preparation of complex molecules.