How big should your screening collection be?

Here’s something that you will never hear said inside a drug discovery group: ‘You know, I’m sure that our screening collection is already large and diverse enough. Let’s just go with what we have.’ At least, I can tell you that I’ve never heard that one – and if I did, I would immediately back away from the person saying it for fear of what they might do next. All things being equal, an opinion like that would be regarded by many as prima facie evidence of mental instability.