Drug discovery and development
The latest chemistry news and research on drug discovery and development, including cancer drugs, antibiotics, vaccines and drug screening, from the Royal Society of Chemistry's magazine, Chemistry World
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FeatureManaging the menopause
The end of ovulation will affect almost all women, but current treatments could be improved. Rachel Brazil reports on the efforts to find a better solution
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OpinionWomen are not just another confounding factor in drug development
Ignoring physiological differences between the sexes is indefensible
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OpinionIn search of truth and rules
To codify and predict ever more complex phenomena is one of science’s great drivers
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BusinessMerck KGaA to buy cancer specialist SpringWorks
$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries
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ResearchLSD analogue synthesised by swapping just two atoms less likely to cause hallucinations
New molecule shows promise for treating neuropsychiatric conditions such as schizophrenia
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WhitepaperOptimise drug discovery: predicting transporter-mediated drug interactions
Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies
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BusinessFree energy methods and digital transformation of drug discovery
Synergistic application of AI-based generative chemistry and free energy methods streamlines molecule discovery and optimisation
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NewsFears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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BusinessAcceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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BusinessEpigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code
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BusinessUS regulatory chief’s resignation raises alarms in biotech industry
FDA vaccines and biologicals centre director, Peter Marks, clashed with health secretary Robert F Kennedy Jr
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OpinionWelcome to the MegaPharm target selection and project resourcing meeting
Overheard recently in a seminar room near you…
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OpinionWeight loss drug supply races
With official shortages ended, but the first generics gearing up for launch, companies are looking for the next generation of drugs
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
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OpinionFluorine makes you an offer you can’t refuse
What might we do if we had a new, electron-donating equivalent element?
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ResearchGenerative AI pipeline creates promising antimicrobial peptides
AI model extrapolates beyond training data to predict diverse antimicrobial structures
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BusinessNew type of painkiller approved in US
Sodium channel blocker prevents nerves transmitting pain signals
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FeaturePutting the F in pharma
Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element
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ResearchMapping metabolite disturbances by drugs
High-throughput metabolomic profiling gives insight into unpredictable drug effects
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ResearchHow AI is transforming chemistry research
Artificial intelligence is revolutionising everything from workflows to networking - so how can you bring AI into your research practice?