All Drug discovery and development articles
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ResearchMolecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
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Opinion
Setting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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Research
Benchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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News
Crispr moves into the clinic
A mere decade after its discovery Crispr is already in clinical trials for everything from sickle cell disease to HIV and cancer
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Research
Universal flu vaccine could head off future pandemics
More effective mRNA-based vaccine offers hope of ending annual flu shots for at risk groups
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Opinion
Embracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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Research
Diverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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Research
Amide library created at speed with machine learning and stopped-flow chemistry
Approach used 90% less starting material than continuous flow equivalent
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Feature
Tiny delivery systems for cancer drugs
Encapsulating anticancer agents in nanoparticles can make them gentler on the rest of the body. Clare Sansom reports
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Opinion
Nobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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Business
Alzheimer’s antibody engenders anticipation
Tantalising press-released data on Biogen and Eisai’s lecanemab prompt questions without firm answers
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Business
An evolution in pharma outsourcing
Contract services firms are becoming increasingly sophisticated and embedded in the ecosystem of drug development
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Opinion
Contribute to defeating malaria
The Medicines for Malaria Venture needs new compounds for screening and more chemists to join its open-souce drug discovery project
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Feature
50 years of artemisinin
Jamie Durrani tells the story of how a wonder drug against malaria was discovered from a plant in a secret Chinese military project
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Research
Yeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
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Webinar
How to profit from recent innovations in small molecule drug discovery
Reduce risk, cost and wasted time in the new era of small molecule drug discovery
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Webinar
Finding new medicines for malaria
Join Chemistry World for this interactive webinar and explore some of the collaborative avenues of research looking for new medicines to prevent and treat one of our oldest foes.
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Business
Protective treatment for Covid-19 makes minimal impact
Limited uptake of antibody combination for vulnerable patients, while demand for antivirals seems to be slowing
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