Drug discovery and development
The latest chemistry news and research on drug discovery and development, including cancer drugs, antibiotics, vaccines and drug screening, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchCovalent drugs just got a new ‘spring-loaded’ warhead
Sulfur(IV) reagent allows late-stage installation of bicyclobutanes to drug molecules, expanding a limited tool box
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BusinessOral cholesterol-lowering peptide approved after a decade in development
Merck & Co’s Lipfendra (enlicitide) employs 13 enzymes in biocatalytic synthesis
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ResearchRe-engineered psychedelic drug retains therapeutic activity in mice, while limiting negative side effects
Rationally designed molecular structure targets a specific subset of serotonin receptors, and potentially offers a route towards safer psychedelic treatments
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WebinarOne goal, three industries: retrosynthesis for pharma, agrochemicals and flavours & fragrances
Join us on 15 September as we explore the latest in AI-powered retrosynthetic software, evaluating its performance across three different industries
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BusinessRegulators push Amgen to withdraw drug due to data manipulation
Questions raised over safety and efficacy of Tavneos (avacopan)
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NewsAston University unveils new £6 million membrane research facility
The facility will investigate membranes for applications such as water purification and drug development
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ResearchProtein wrappers designed by AI solve membrane proteins’ solubility problem
Protein sheaths encapsulate membrane proteins while preserving their structure and function making them easier to study
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BusinessRewriting genetic medicine
Scribe Therapeutics will soon begin clinical trials for its epigenetic treatment to tackle ‘bad’ cholesterol
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ResearchMetabolised antibiotics can drive antimicrobial resistance just as much as their parent compounds
Studies on wastewater show that antibiotic transformation products may play an underappreciated role in driving antimicrobial resistance
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ResearchClever chemistry turns antibiotic-resistant bacteria’s own defences against them
Photosensitiser is activated by enzyme linked to resistance, making bacteria vulnerable to light therapy
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OpinionWhat kinds of reactions do you do most?
Variety may be the spice of life, but there’s space for the boring but effective
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OpinionGSK agrees $10 billion deal for Nuvalent cancer drugs
Deal includes two late-stage molecules to augment GSK’s renewed cancer therapy pipeline
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NewsCroatian researchers thrust into limelight as their 1990s’ peptide discovery goes mainstream in the US
Trump administration hopes to approve peptides popular with MAHA wellbeing advocates. How are the researchers at the centre of this coping with sudden media fame?
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NewsWhat kind of damage has RFK Jr’s health department inflicted on vaccine research in the US so far?
Since becoming health secretary in early 2025, Robert F Kennedy Jr has confirmed the worst fears of his critics
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BusinessUS FDA commissioner Makary resigns amid chaos and questions
Marty Makary’s departure, amid reports that Trump planned to fire him, is the result of an ‘inherited crisis’ and ‘shifting FDA standards’, BIO says
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ArticleAdvantages of monodisperse PEG in drug development
Precision matters: why monodisperse PEG is transforming drug development.
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Business‘Basic research is needed more than anything else’
Christian Hackenberger, co-founder of Tubulis, is excited that his team’s initial research is now creating clinical impact
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PodcastVanadium-based medicines & sustainable labs
Vanadium-based medicines? We discuss the 23rd element’s little-known potential in pharmaceuticals. Plus, how labs across the UK are making achievable changes to increase their sustainability.
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OpinionThe evolving landscape of pain drug discovery
Harnessing the power of human-relevant in vitro models
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OpinionMajor drug regulators advancing routes to reduce animal testing
US, UK and EU all have goals to eliminate animal testing