Drug discovery and development
The latest chemistry news and research on drug discovery and development, including cancer drugs, antibiotics, vaccines and drug screening, from the Royal Society of Chemistry's magazine, Chemistry World
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Research
Companion compound for naloxone could boost opioid reversal effects, save lives
Discovery could help in fight against super-strength opioids such as fentanyl
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Feature
Bypassing the blood–brain barrier
Researchers are on a quest to outsmart and overcome the sophisticated security system of the brain. Julia Robinson reports on some of the approaches being studied
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Feature
The high price of a suntan
Skin cancer is on the rise in many countries around the world, but so are the methods to treat it. Bárbara Pinho reports
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Business
Moderna’s mRNA vaccine approved for RSV
US approval adds complementary option to protein-based vaccines for respiratory syncytial virus
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Research
Conjugate vaccine curbs xylazine effects in mice
Proof-of-concept for therapy that harnesses immune system to fight fentanyl adulterant
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Opinion
Will science ever reach an end?
While the rate of discoveries in any field may slow over time, the frontier creeps ever further
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Business
Pan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location
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Research
‘Late-stage saturation’ could improve drugs' effectiveness
Approach turns flat aromatic structures into three-dimensional saturated molecules with improved medicinal properties
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Research
How HIV drugs have changed over the decades
From one big pill that only prolonged lives a few months, through the 20 pills a day years to modern combination therapies, treating HIV is a science success story
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Opinion
Lab automation gives me more time at the top of the mountain
Getting back to the bench reminds Derek Lowe how much has changed in 40 years
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Research
Screening reveals thousands of ‘undrugged, yet druggable’ proteins
Collaboration involving Pfizer develops freely accessible AI tool to probe protein–compound interactions
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News
Explainer: nitazenes and xylazine – a cause for concern
Why is the use of these highly potent synthetic drugs rising dramatically?
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Research
Cross-coupling technique cracks open alcohols for chemical synthesis
A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists
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Research
Non-antibiotics with antibacterial activity could help in the fight against antimicrobial resistance
New analysis shows that non-antibiotic drugs kill bacteria through mechanisms that differ from those of conventional antibiotics
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Opinion
Harnessing biodiversity through natural products research in the Philippines
Collaborative projects aim to produce cheaper and more effective medicines
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Research
Classic cross-coupling reactions rerouted to make new products
Combination of Suzuki–Miyaura and Buchwald–Hartwig couplings produces carbon–nitrogen–carbon linked compounds
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Opinion
From one sinking ship to another?
Biogen abandoning Alzheimer’s antibody aducanumab is unusual, but hardly surprising, says Derek Lowe
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Business
Big deals confirm renewed interest in radiopharmaceuticals
Acquisitions of RayzeBio and Point Biopharma highlight the potential of targeting radioactivity directly to tumour cells
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Research
Pre-organising antibiotic structure could aid fight against resistance
Strategy that produced new antibiotic could allow researchers to repurpose existing antibiotics
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Feature
More than a mirror-image: left-handed nucleic acids
Now a biological reality, researchers are starting to figure out the many roles of left-handed nucleic acids such as Z-DNA – from immunity to controlling our genetics. Rachel Brazil reports