All Reactions and synthesis articles
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ResearchEnantioselective synthesis of elusive chiral nitrogen compounds discovered by chance
An ‘elegant and simple’ way to make nitrogen stereocentres by supramolecular recognition
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Research
Electrons in zinc’s filled 3d orbitals can participate in chemical reactions
Super electrophilic trianions accept three additional electrons to support zinc in a +3 oxidation state
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Research
Blue light squeezes out heteroatoms from small rings
Photochemical ring editing reaction allows complete molecular shape change in a single step
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Research
Gold(III) catalysis transforms protecting group from base-stable to base-labile
Unique orthogonality in a protecting group achieved using a gold-catalysed cyclisation for selective activation and deprotection
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Research
Molecular cryo-EM discovers error in 25-year-old natural product structure
Nobel prize-winning biomolecule imaging technique adapted to characterise chemical compounds faster and easier than NMR and x-ray
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Research
Photocatalyst couples denitrification and water splitting to manage nitrate pollution
Hydrogen gas generated in situ serves as reducing agent
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Opinion
Appreciating sterics
How can chemists quantify steric effects when they struggle to define them?
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Research
Mirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages
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Research
Heavy-atom quantum tunnelling catalysed with Lewis acids
Lewis acid–base interactions found to increase quantum tunnelling rates of rearrangement reaction
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Research
Safer fluorination process developed using flow electrochemistry
Automated system for constructing carbon–fluorine bonds quenches fluorine compounds to reduce exposure and risk to lab chemists
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Research
Metal sandwich stabilises first benzene triplet-state aromatic
Benzene diradical dianion is the first monocyclic molecule that’s Baird aromatic in the ground state
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Research
Transient spectroscopy sheds light on elusive photoredox process
Study confirms mechanism of sensitisation-initiated electron transfer reaction following extended debate
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Research
Electrocatalysis offers green alternative for ethylene purification
Copper catalysts enable selective and efficient acetylene reduction at ambient conditions
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Research
Molecular light switch speeds up tricky cyclodextrin synthesis
Reaction could lower cost of useful macrocycle
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Research
Aluminium compound deconstructs sulfur hexafluoride in minutes
Method turns potent greenhouse gas into useful synthetic reagents
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Research
Chemists control reaction path with mechanical force
Mechanochemical mechanism exploited to access unconventional trajectories on a reaction’s potential energy surface
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Research
Glass catalysis screening study prompts reactionware rethink
Base-catalysed reactions are up to 1000 times faster in the presence of glass
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Research
Origin of mysterious alpha effect in nucleophilic substitution reactions unveiled
Alpha nucleophiles’ ability to get close to electrophiles – rather than their intramolecular lone pair repulsion – gives them unusual reactivity
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Research
From nerve agent simulant, to pharma ingredient
Portable microreactor offers a new way to dispose of paraoxon
![An image showing a [M2(BzN6-Mes)]n− complex](https://d2cbg94ubxgsnp.cloudfront.net/Pictures/100x67//4/0/8/514408_index_128835.jpg)
