All Reactions and synthesis articles
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ResearchSynthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
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Research
‘Inside-out’ chirality discovered by chance could have been missed in many molecules
A structure assignment odyssey finds a natural product with a type of isomerism never before seen in small molecules
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Research
Mixed oxidation states expand repertoire of hypervalent iodine reagents
Iodine(iii) and iodine(v) coexist in new nitroiodoxybenzene-based oxidant
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Research
Program finds 5 million synthetic routes to complex chemicals
Only around five hundred ‘tactical combinations’ for advanced organic synthesis existed – until Chematica was let loose on the problem
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Research
Compact pharmaceutical factory manufactures drugs on demand
Plant with modular design would occupy about half the area of a squash court
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Research
Grinding out single-atom catalysts made simple by ball mill
No compromise on quality of heterogeneous catalysts made on kilogram scale
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Research
Total synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
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Research
Catalyst breaks sulfur–sulfur bonds to give new life to tired tyres
Process recovers organic components that can become new elastomers
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Research
Intense sound fields make mercury react with water
After nearly a century, scientists can explain why a grey cloud forms when mercury and water are sonicated
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Research
Simple way to construct molecules with perfluoroalkyl bridges
Troublesome side reaction becomes useful synthetic tool
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News
Open access Atlas maps out microbial natural products
Project aims to accelerate research on microbial metabolites
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Research
‘Ideal’ water splitting catalysts actually exist, simulations find
New computational model could accelerate the discovery of cheaper and more efficient catalysts
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Opinion
Cleaning up chemical kitchens
In a busy plant, ensuring small changes don’t produce unforeseen toxic impurities is key
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Research
Flow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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Research
Total synthesis of unnatural enantiomer renews interest in quinine
Scientists hope their strategy will invigorate cinchona alkaloid-mimic catalysis
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Research
Chemists taken aback as dinitrogen found to speed up some reactions
Warnings that nitrogen should no longer be considered just an inert carrier gas
