All Reactions and synthesis articles
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ResearchCarbynes expand the possibilities of carbon–carbon double bonds
Chemists use novel monovalent carbon species to insert functionalities in the middle of double bonds
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Research
Alzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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Opinion
Stille cross-coupling
Palladium and tin combined to lay the foundations for a revolution in C–C bond-forming reactions
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Research
First synthesis of unusual natural product could revive forgotten eco-friendly insecticide class
16-step synthesis of rare diterpene could reveal new ways to control insecticide-resistant pests
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Research
Template molecules round-up extra-large cyclodextrins from enzymatic synthesis
Scientists rethink how they use enzymes in chemical synthesis by exerting thermodynamic, rather than kinetic, control
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Webinar
Fundamentals and applications of photoredox catalysts in organic and macromolecular synthesis
Join us on 29 October at 4pm to learn about the fundamentals of photoredox catalysts for their application in organic synthesis
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Research
Universal method bypasses obstacles to making neglected hydrocarbon skeletons
Universal method bypasses obstacles to making neglected hydrocarbon skeletons
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Opinion
Embracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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Research
Human biases cause problems for machines trying to learn chemistry
Including ‘unpopular’ reagents and reaction conditions into datasets could lead to better machine-learning models
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Opinion
Stereoselectivity with a twist
Helical ligands amplify solvent chirality to control reaction outcomes
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Research
Water surprise: microdroplets have potential to produce H2O2
US researchers discover that microscopic droplets of water spontaneously generate hydrogen peroxide
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Research
Solution to 120 year-old puzzle reveals new chemical phenomenon
Seemingly identical acetaldehyde phenylhydrazone crystals melt at different temperatures
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Webinar
Modern computational workflows for molecular design using the Schrödinger platform
Learn how Schrödinger’s computational platform can accelerate drug discovery and molecular design projects
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Research
New carbodiphosphoranes break superbasicity record
Chemists overcome synthetic challenges to make uncharged carbon molecules that sit at far end of THF basicity scale
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Research
Solid-state electrochemical cells convert carbon dioxide into valuable liquid fuels
Process dodges product separation challenges
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Research
Catalyst cleans up alcohol couplings
Eight years’ work yields Mitsunobu chemistry with nothing but water as a byproduct
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Sponsored
AstraZeneca conference – New frontiers in synthetic chemistry
Academia and industry meet to solve the challenges of modern drug discovery and process chemistry
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Research
Carbon dioxide serves as carbonyl source in frugal process for making aromatic esters
Nanoscale confinement triggers strong base reactivity in process that shuns stoichiometric consumption of resource intensive reagents
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Research
Solo palladium in catalytic copper alloy reduces nitric oxide from vehicle exhausts
First system to work at low temperatures that doesn’t generate nitrous oxide
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Research
Retrosynthetic algorithm broadened to design similar, but different, molecules
Chematica can now design efficient syntheses for large compound libraries
