Total synthesis
The latest chemistry news and research on total synthesis, including stereochemistry, new methodology, protecting groups and asymmetric synthesis, from the Royal Society of Chemistry's magazine, Chemistry World
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Opinion(−)-Novofumigatonin
Oxidations abound in this satisfying synthesis, with a delicate nitrile hydrolysis to finish
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WhitepaperAdQPhos: Exceptional performance in α‑arylation reactions
Download now to discover a more efficient and greener palladium cross-coupling catalyst
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ResearchTotal synthesis of anti-addictive alkaloid in just seven steps
A streamlined synthesis of the psychoactive compound ibogaine could open up new opportunities in the treatment of drug addiction and depression
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Opinion(–)-Scabrolide B (again!)
Proverbially, comparison may not bring joy – but it can be educational
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WhitepaperIlluminating progress: recent advances in photoredox catalysis
In this free download, shed some light on the latest developments in photoredox for drug development and materials science
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WhitepaperElectrochemistry: a powerful addition to the synthetic chemistry toolbox
In this free download, discover how advancements in electrochemical techniques can broaden the scope and impact of chemical synthesis
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WhitepaperOptimising synthesis: SYNTHIA & green chemistry
Reduce step counts, improve yields and atom economy while reducing environmental impact, all with a little computational help
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ResearchStudy questions sustainability benefits of replacing palladium with nickel in cross-coupling reactions
Common belief that Earth-abundant metals are green replacements for palladium may be misleading
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ResearchFirst GPT-4-powered AI lab assistant independently directs key organic reactions
Large language model takes control after being prompted to do Suzuki and Sonogashira couplings
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Opinion(+)-iso-Phomopsene (and friends)
A non-obvious combination unleashes the power of electrocyclisation
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FeatureEditing the structure of molecules
Nina Notman meets the chemists expanding the toolbox of reactions capable of adding, deleting and switching single atoms in rings at the heart of organic molecules
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ResearchStreamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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ResearchChirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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ResearchControversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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