Total synthesis – Page 5
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Opinion
Pactamycin
Labelling a molecule 'inaccessible to synthesis' is a red rag to a bull, says Paul Docherty
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Opinion
Pentalenolactone A methyl ester
Paul Docherty revises a reaction he never could quite remember
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FeatureStepping toward ideality
James Mitchell Crow wonders what would make the perfect organic synthesis
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Opinion
atrop-Abyssomicin C
Natural products frequently have hard to pronounce and even harder to spell names, often of little meaning.
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Opinion
Indoxamycin B
It has always been the rearrangement reactions that did their best to elude my eye
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Opinion
Scholarisine A
Ring strain is a fascinating phenomenon - one that is best understood with plastic modelling kits, wearing safety specs for ring sizes of four or less. These smaller rings are packed with energy, resulting from both tight bond angles (deviating from the tetrahedral ideal of 109.5?), and ...
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OpinionAsteriscunolide D
Medium rings are a beguiling feature found in a host of natural products, owing to their behavioural oddities. While the properties and synthesis of smaller rings (three to six atoms in size) are well known, and that of true macrocycles can at least be estimated, each medium ...
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OpinionDragmacidin D
Why do we make functional groups? That might come across as the dumbest question of the year, but there’s actually a point behind it. The majority of functional groups present in the synthetic intermediates in a synthesis don’t make it to the target - they are consumed, ...