Total synthesis – Page 5

  • 0813CW-COMMENT_Karl-Collins_300
    Opinion

    An 'Aye' for details

    2013-07-10T00:00:00Z

    Small steps by synthetic chemists could mean giant leaps for those who follow, says Karl Collins

  • Opinion

    Bolivianine

    2013-06-27T00:00:00Z

    A complex terpene gives Paul Docherty a headache

  • Opinion

    Pactamycin

    2013-05-29T00:00:00Z

    Labelling a molecule 'inaccessible to synthesis' is a red rag to a bull, says Paul Docherty

  • Opinion

    Kingianin A

    2013-05-01T00:00:00Z

    Paul Docherty faces his fears of frontier molecular orbital theory

  • Opinion

    Acutumine

    2013-03-22T00:00:00Z

    Polycyclic acutumine ties Paul Docherty up in knots

  • Opinion

    Lyconadin A again

    2013-02-28T00:00:00Z

    Paul Docherty tackles a serious repeat offender

  • Opinion

    Hyperforin

    2013-01-24T00:00:00Z

    A flexible natural product synthesis is the key to later drug development

  • Opinion

    Flueggine A

    2013-01-02T00:00:00Z

    Some exotic heterocyclic chemistry catches Paul Docherty's eye

  • Opinion

    Pentalenolactone A methyl ester

    2012-11-27T00:00:00Z

    Paul Docherty revises a reaction he never could quite remember

  • Opinion

    Epicoccin G

    2012-10-31T00:00:00Z

    Paul Docherty gets to grips with some thiodiketopiperazines

  • Opinion

    Prostaglandin F2α

    2012-10-01T00:00:00Z

    Paul Docherty comes face to face with an old adversary

  • Opinion

    Amphidinolide F

    2012-08-29T00:00:00Z

    Symmetry in natural products isn’t always so apparent

  • Opinion

    Marinomycin A

    2012-07-27T00:00:00Z

    Faced with the term ‘polymer’, most people would consider man-made materials

  • 0812CW_FEATURE_Organic-Synthesis_Fig1_630
    Feature

    Stepping toward ideality

    2012-07-06T00:00:00Z

    James Mitchell Crow wonders what would make the perfect organic synthesis

  • Opinion

    Vincorine

    2012-07-01T00:00:00Z

    Cage-structured natural products are some of the most appealing targets for organic chemists

  • Opinion

    atrop-Abyssomicin C

    2012-05-31T00:00:00Z

    Natural products frequently have hard to pronounce and even harder to spell names, often of little meaning.

  • Opinion

    Hopeahainol A and hopeanol

    2012-04-30T00:00:00Z

    This month's synthesis looks somewhat familiar

  • Opinion

    Indoxamycin B

    2012-03-31T00:00:00Z

    It has always been the rearrangement reactions that did their best to elude my eye

  • Opinion

    Scholarisine A

    2012-02-23T13:01:00Z

    Ring strain is a fascinating phenomenon - one that is best understood with plastic modelling kits, wearing safety specs for ring sizes of four or less. These smaller rings are packed with energy, resulting from both tight bond angles (deviating from the tetrahedral ideal of 109.5?), and ...

  • TOTALLY-SYN_180
    Opinion

    Asteriscunolide D

    2012-01-27T10:21:00Z

    Medium rings are a beguiling feature found in a host of natural products, owing to their behavioural oddities. While the properties and synthesis of smaller rings (three to six atoms in size) are well known, and that of true macrocycles can at least be estimated, each medium ...