Total synthesis – Page 3
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OpinionChanging the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
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ResearchWhat’s left isn’t always right in total synthesis
Scientists turn detective to solve a decade-old stereochemical enigma
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OpinionNatural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
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Opinion(‒)-Pavidolide B
An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis
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ResearchRoute to fiendishly complex marine molecule cut in half
Shortcut to promising natural product already in Alzheimer’s and HIV trials
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OpinionForcing fluorines into shape
Sometimes unnatural molecules can be more challenging to synthesise than natural metabolites
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Opinion(+)-Pleuromutilin
Total synthesis is sometimes the only way to explore the chemical space around a natural product
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BusinessMerck KGaA to buy Chematica
Retrosynthesis tool will gain computational muscle and integrate with Sigma–Aldrich catalogue
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ResearchHow total synthesis is creating antibiotics
Macrolide synthesis could reinvigorate the antibiotic pipeline
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Opinion(+)-Zincophorin methyl ester
New and old reactions combine for an elegant and concise synthesis
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ResearchTamed radicals expand chemical space
A method to functionalise complex molecules with catalytic radicals could expand chemical libraries of the drug and agrochemical industry
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ResearchBatch and flow: united at last
Fully automated reactor can carry out multistep reactions using both batch and flow chemistry
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OpinionHome synthesis is here – we must guide it
On-demand chemistry raises as many questions as it answers
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Opinion6-epi-Ophiobolin N
When it comes to cascade reactions, radicals are king of the ring-formers
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ResearchArduous natural product quest's unwelcome end
Thousands of experiments help find conditions to make (–)-maoecrystal V
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ResearchChemists hit a top synthetic target with pyramidal compounds
Non-classical covalent pyramidanes surprise with high bonding ionicity
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FeatureOrganic odysseys
Andy Extance looks at two drugs that cranked the synthetic challenge all the way up to Halaven
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ResearchChemistry's toughest total synthesis challenge put on hold by lack of funds
‘Seemingly impossible’ synthesis of highly potent poison maitotoxin nears completion after eight years