All Total synthesis articles – Page 3
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Opinion(‒)-Pavidolide B
An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis
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Research
Route to fiendishly complex marine molecule cut in half
Shortcut to promising natural product already in Alzheimer’s and HIV trials
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Opinion
Forcing fluorines into shape
Sometimes unnatural molecules can be more challenging to synthesise than natural metabolites
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Opinion
(+)-Pleuromutilin
Total synthesis is sometimes the only way to explore the chemical space around a natural product
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Business
Merck KGaA to buy Chematica
Retrosynthesis tool will gain computational muscle and integrate with Sigma–Aldrich catalogue
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Research
How total synthesis is creating antibiotics
Macrolide synthesis could reinvigorate the antibiotic pipeline
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Opinion
(+)-Zincophorin methyl ester
New and old reactions combine for an elegant and concise synthesis
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Research
Tamed radicals expand chemical space
A method to functionalise complex molecules with catalytic radicals could expand chemical libraries of the drug and agrochemical industry
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Research
Batch and flow: united at last
Fully automated reactor can carry out multistep reactions using both batch and flow chemistry
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Opinion
Home synthesis is here – we must guide it
On-demand chemistry raises as many questions as it answers
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Opinion
6-epi-Ophiobolin N
When it comes to cascade reactions, radicals are king of the ring-formers
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Research
Arduous natural product quest's unwelcome end
Thousands of experiments help find conditions to make (–)-maoecrystal V
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Research
Chemists hit a top synthetic target with pyramidal compounds
Non-classical covalent pyramidanes surprise with high bonding ionicity
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Feature
Organic odysseys
Andy Extance looks at two drugs that cranked the synthetic challenge all the way up to Halaven
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Research
Chemistry's toughest total synthesis challenge put on hold by lack of funds
‘Seemingly impossible’ synthesis of highly potent poison maitotoxin nears completion after eight years
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Feature
Unpicking natural product synthesis
Is total synthesis in danger of a decline? Nina Notman investigates
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Podcast
Chemistry World podcast - May 2014
We speak to the ‘sultan of synthesis’, Phil Baran, and Peter James explains how labs can save cash on energy bills
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Feature
The sultan of synthesis
Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers
