Total synthesis – Page 3
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Research
American Civil War era tea yields modern day medicine
Macrocyclisation strategy key to obtaining long known alkaloid with untapped potential
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Opinion
Changing the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
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Research
What’s left isn’t always right in total synthesis
Scientists turn detective to solve a decade-old stereochemical enigma
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Opinion
Natural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
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Opinion
(‒)-Pavidolide B
An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis
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Research
Route to fiendishly complex marine molecule cut in half
Shortcut to promising natural product already in Alzheimer’s and HIV trials
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Opinion
Forcing fluorines into shape
Sometimes unnatural molecules can be more challenging to synthesise than natural metabolites
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Opinion
(+)-Pleuromutilin
Total synthesis is sometimes the only way to explore the chemical space around a natural product
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Business
Merck KGaA to buy Chematica
Retrosynthesis tool will gain computational muscle and integrate with Sigma–Aldrich catalogue
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Research
How total synthesis is creating antibiotics
Macrolide synthesis could reinvigorate the antibiotic pipeline
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Opinion
(+)-Zincophorin methyl ester
New and old reactions combine for an elegant and concise synthesis
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Research
Tamed radicals expand chemical space
A method to functionalise complex molecules with catalytic radicals could expand chemical libraries of the drug and agrochemical industry
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Research
Batch and flow: united at last
Fully automated reactor can carry out multistep reactions using both batch and flow chemistry
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Opinion
Home synthesis is here – we must guide it
On-demand chemistry raises as many questions as it answers
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Opinion
6-epi-Ophiobolin N
When it comes to cascade reactions, radicals are king of the ring-formers