Biology – Page 11
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BusinessPatent office cements priority for Crispr gene editing in cells
Nobel laureates’ failed challenge means companies may need extra patent licenses
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FeatureThe curious case of the ancient brain
A 2000 year old decapitated Yorkshire man and the ancient proteins in his preserved brain might provide clues to modern diseases, as Hayley Bennett discovers
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BusinessModerna sued over Covid-19 vaccine-related patents
Arbutus and Genevant say lipid nanoparticles that protect mRNA infringe six key patents
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ResearchEpigenetic MRI offers a way to understand how the brain learns
First tests in humans could be as little as year away, researchers claim
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ResearchReprogrammed bacterium turns carbon dioxide into chemicals on industrial scale
Process achieved at industrial scale in 120 litre reactor
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ResearchElectric field of ATP synthase suggests enzyme has functions beyond catalysis
Study links energy-making enzyme with proton migration in ATP formation, and reinforces predictions that its catalytic efficiency is around 90%
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FeatureSequencing one cell at a time
New advances that allow scientists to uncover the molecular differences between individual cells could revolutionise medicine, Ian le Guillou finds
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ResearchBiochemical secrets of tarantula’s painful bite could point to perfect painkillers
King baboon spider venom could help scientists develop potent analgesics
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ResearchNew microscope makes tracking chiral molecules in live cells possible
The instrument uses circularly polarised light to tell left- and right-handed species apart and monitor them in space and time
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ResearchLeft-handed nanoparticles are far better vaccine adjuvants than their mirror images
Chiral gold nanoparticles shown for the first time to elicit differing immune responses in cells and live mice
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OpinionThe shadow of drug resistance
Why do some medicines stop working, and can we avoid it for Covid-19 antivirals?
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ResearchEngineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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ResearchEvolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions
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FeatureHow protocells bridge the gap from chemistry to biology
Rachel Brazil talks to the scientists trying to recreate what the first cells were like, or to make their own versions
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OpinionNed Seeman’s legacy
A system based on DNA ‘tiles’ can embody Darwinian evolution, raising new possibilities for understanding natural selection and materials development
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ResearchListening to quantum beats could reveal rhythm of birds’ migratory compass
Laser technique to read out oscillating spin states could help uncover how animals’ magnetic sense works
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ResearchSingle-celled marine organism first to be found releasing oxygen in the dark
Discovery of new biological pathway in widespread archaea could transform understanding of oceans’ fertility
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ResearchHeavy oil-eating microbe grown in lab for the first time
Archaeon that breaks down long alkanes into methane and carbon dioxide could be used for energy recovery from depleted oil reservoirs
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OpinionJune Lindsey, another forgotten woman in the story of DNA
Her discovery of adenine and guanine’s structure was a key part of solving the DNA double helix puzzle – yet her contributions are almost forgotten
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NewsReplication failures cast doubt on some cancer studies
Just 18% of experiments from top papers met all criteria for successful replication