Biology – Page 14
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ResearchTheories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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ResearchMystery of how plants make strychnine solved 75 years after characterisation
Three-quarters of a century after Robinson and Woodward cracked structure chemists unravel poison’s biosynthesis
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ResearchRenewable rocket fuel made by genetically engineered soil bacteria
Bioengineered bacteria synthesise extremely energy dense cyclopropane chains
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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ResearchThe odour of amity: how you smell can predict friendships
Strangers who smell alike tend to form an instant connection with each other on first meeting
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ResearchEncapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
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OpinionFrom prebiotic soup to fine-grained RNA world
Theories about how life emerged need to be closely attuned to conditions on the early Earth
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ResearchLight-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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ResearchFossil molecules reveal dinosaurs’ bird-like metabolism
Thioethers preserved in bones show that most dinosaurs were warm-blooded, though T rex may have been particularly sluggish
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ResearchBreaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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ResearchGene therapy showcases technique to extend life in mice
Lab mice lived significantly longer after receiving one of two genes, delivered using a mouse herpes virus
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BusinessWhat is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
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OpinionAn idea that clicked
Bioorthogonal reactions – doing chemistry inside living cells without blasting everything in sight – are no mean feat
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OpinionCarolyn Bertozzi: ‘Shooting hoops is very meditative’
The celebrated chemical biologist who dreamed of being a rock star before inventing the field of bioorthogonal chemistry
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FeatureThe bioorthogonal revolution
A set of reactions operating silently inside live cells or whole animals are lighting up chemical biology and inspiring new medicines, James Mitchell Crow finds
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OpinionIs there a natural order in which complex objects appear?
Assembly theory suggests there might be
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Feature3D printing adds another dimension
Nina Notman learns how 4D printing is opening the door to unique smart materials whose applications may only be limited by our imaginations
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ResearchCancer progression and harmful bacteria tracked with next-generation sequencing
Proof-of-principle study keeps an eye on leukaemia mutations and bacterial strains in patients