All directed evolution articles
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ResearchArtificially expanded genetic alphabet evolves enzymes for the first time
Libraries of short DNA sequences incorporating synthetic nucleotides perform better as enzymes than ordinary DNA
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchNMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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ResearchEngineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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ResearchEvolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions
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FeatureArtificial enzymes: catalysis by design
Enzymes are nature’s ultimate catalysts and chemists are now on the verge of making their own versions from scratch
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ResearchResurrected enzyme aces cellulose catalysis
Protein that survived extreme conditions on early Earth could be a boon for biofuel industry
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ResearchEnzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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ResearchEnzyme redesign magnifies rare sugar synthesis
Tweaks could allow scientists to explore the commercial potential of an unusual disaccharide found in Japanese sake
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NewsIupac names 10 chemistry innovations that will change the world
Nanopesticides, MOFs and 3D bioprinting among potential breakthrough technologies for a sustainable future
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ResearchEnzyme evolved that can perform reactions new to nature
New possibilities for organic synthesis with enzymatic C–H functionalisation
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ResearchEnzyme ancestors resurrected to boost thermal stability
Scientists constructing enzyme library make serendipitous discovery