All enzymes articles
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ResearchAI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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Research
Yeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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Research
IBM teaches reaction planning system to ‘speak enzyme’
RXN seeks to use enzyme catalysis to make chemistry more sustainable and resource efficient
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Research
Electric field of ATP synthase suggests enzyme has functions beyond catalysis
Study links energy-making enzyme with proton migration in ATP formation, and reinforces predictions that its catalytic efficiency is around 90%
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Research
Engineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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Research
Evolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions
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Feature
The labs pointing to a greener future for Africa
Tackling climate is not just a job for scientists in more developed countries. Munyaradzi Makoni talks to researchers in Kenya and South Africa to find out more
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Research
Giant molecular cage protects plastic-eating enzyme
Caged protein withstands temperatures much hotter than its usual melting point and becomes 1000 times more resistant to solvents
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Research
Mirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages
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News
Machine learning delivers ‘human genome’ moment for proteins
Protein structure prediction tools AlphaFold and RoseTTAFold take the latest steps towards maturity and make their software open source
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Research
Molecular light switch speeds up tricky cyclodextrin synthesis
Reaction could lower cost of useful macrocycle
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Business
Engineering microbes to degrade contaminants
Allonnia is using synthetic biology to tackle major environmental challenges like PFASs, metals and plastic waste
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Research
Sortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
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Research
Artificial enzyme sets record as it outperforms horseradish counterpart by factor of 12
Engineered nanoparticle achieves highest efficiency of any artificial enzyme when compared with natural peroxidase
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Research
The hole story of how cage molecules could transform synthesis and separation
Chemists are getting to grips with how to put molecules inside other molecules and how this could protect highly reactive reagents and create enzyme-like catalysts
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Research
New titration reagent helps identify the best amylase for the job
Fluorogenic compound plugs gap in industrial enzyme screening toolbox
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Feature
Unnatural selection in chemical systems
Great strides have been made in the lab with chemical systems that ape life’s behaviour
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Feature
Artificial enzymes: catalysis by design
Enzymes are nature’s ultimate catalysts and chemists are now on the verge of making their own versions from scratch
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Feature
Homogeneous C–H activation
In the final instalment of our grails series we look at how picking and choosing which bond to target holds the promise of transforming organic molecules at will
