All enzymes articles
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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Research
NMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
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Research
Designer catalyst with enzyme-like cavity splits water almost as fast as plants
Catalytic cleft offers new strategy to speed up hydrogen synthesis
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Research
Artificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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Research
Nature inspires greener generation of metal hydrides to make formic acid from CO2
The iron–sulfur cluster catalyses the electrocatalytic formation of manganese hydrides
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Research
Theories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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Research
Microdroplets tackle scale-up issues for enzyme-photocoupled catalysis
Gas-spray reactor enhances light illumination efficiency and boosts rate of reaction
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Research
AI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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Research
Yeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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Research
IBM teaches reaction planning system to ‘speak enzyme’
RXN seeks to use enzyme catalysis to make chemistry more sustainable and resource efficient
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Research
Electric field of ATP synthase suggests enzyme has functions beyond catalysis
Study links energy-making enzyme with proton migration in ATP formation, and reinforces predictions that its catalytic efficiency is around 90%
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Research
Engineered enzyme speeds up sedate organic reaction
Biochemical optimisation applied to the Morita–Hillman–Baylis reaction
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Research
Evolved enzymes carry out new-to-nature radical chemistry
Directed evolution produces enzymes that can ‘tame’ radical intermediates for asymmetric catalytic reactions
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Feature
The labs pointing to a greener future for Africa
Tackling climate is not just a job for scientists in more developed countries. Munyaradzi Makoni talks to researchers in Kenya and South Africa to find out more
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Research
Giant molecular cage protects plastic-eating enzyme
Caged protein withstands temperatures much hotter than its usual melting point and becomes 1000 times more resistant to solvents
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Research
Mirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages
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News
Machine learning delivers ‘human genome’ moment for proteins
Protein structure prediction tools AlphaFold and RoseTTAFold take the latest steps towards maturity and make their software open source
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Research
Molecular light switch speeds up tricky cyclodextrin synthesis
Reaction could lower cost of useful macrocycle
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Business
Engineering microbes to degrade contaminants
Allonnia is using synthetic biology to tackle major environmental challenges like PFASs, metals and plastic waste
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Research
Sortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
