All enzymes articles
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ResearchTeaching enzymes new reactions through genetic code expansion and directed evolution
Anthony Green’s research group at the University of Manchester, UK, reengineers enzymes to have catalytic functions beyond those found in nature
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OpinionEnormous enzymes expand the limits of molecular biology
Identifying the PKZILLAs, used by algae to make toxins, stretched the capabilities of current analytical methods – and the limits of our preconceptions
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ResearchMicrobial enzymes cut a path towards universal blood for transfusions
Slicing off glycans revealed new, previously unknown antigens that must be removed to produce O-type blood
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ResearchLight-driven enzyme engineered and repurposed to catalyse unnatural reaction
Directed evolution used to create photoenzyme that can perform new-to-nature radical cyclisation
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ResearchUnravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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ResearchChemical industry hasn’t yet developed an appetite for biocatalysis, survey finds
Misconceptions along with a lack of time and resources driving industry’s reluctant attitude to biocatalysis and chemoenzymatic catalysis
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BusinessRecycling plastic with enzymes
Carbios can return even hard-to-recycle polyester fibres and textiles to their constituent monomers
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FeatureFixing nitrogen fixing
Green ammonia promises a more sustainable future. Jamie Durrani talks to the researchers aiming to revolutionise the production of crucial fertiliser
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ResearchNMR reveals sialic acid biosynthesis in real time
Using NMR, scientists can directly measure sialic acid enzyme conversion velocities for the first time
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ResearchUnexpected autocatalytic effect gives light-driven enzyme a boost to synthesise green fuels
Discovery could enhance production of liquid fuels by algae
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchNMR spectroscopy used to guide evolution of better enzymes
Identifying mutagenic ‘hotspots’ could speed development of new proteins
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ResearchDesigner catalyst with enzyme-like cavity splits water almost as fast as plants
Catalytic cleft offers new strategy to speed up hydrogen synthesis
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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ResearchNature inspires greener generation of metal hydrides to make formic acid from CO2
The iron–sulfur cluster catalyses the electrocatalytic formation of manganese hydrides
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ResearchTheories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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ResearchMicrodroplets tackle scale-up issues for enzyme-photocoupled catalysis
Gas-spray reactor enhances light illumination efficiency and boosts rate of reaction
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ResearchAI-engineered enzyme eats entire plastic containers
Enzyme with only five amino acid alterations depolymerises 51 different PET products faster and at lower temperature than other proteins
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ResearchYeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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ResearchIBM teaches reaction planning system to ‘speak enzyme’
RXN seeks to use enzyme catalysis to make chemistry more sustainable and resource efficient