All Total synthesis articles
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FeatureEditing the structure of molecules
Nina Notman meets the chemists expanding the toolbox of reactions capable of adding, deleting and switching single atoms in rings at the heart of organic molecules
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ResearchStreamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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ResearchChirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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ResearchControversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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OpinionCatalogues of complexity
The tangled web of fine chemicals supply frequently throws up surprises
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OpinionExit strategy
Overcoming a major setback showed Derek Lowe could make it through graduate school
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OpinionFully automated synthesis of fluorine-18 PET tracers
Making radioisotopes suitable for positron emission tomography
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OpinionTheodora Greene’s protecting groups
Katrina Krämer uncovers the woman behind the book on every organic chemist’s shelf
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ResearchChemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies