All Total synthesis articles
View all stories with this category.
-
Research‘Inside-out’ chirality discovered by chance could have been missed in many molecules
A structure assignment odyssey finds a natural product with a type of isomerism never before seen in small molecules
-
Research
Program finds 5 million synthetic routes to complex chemicals
Only around five hundred ‘tactical combinations’ for advanced organic synthesis existed – until Chematica was let loose on the problem
-
Research
Total synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
-
-
Research
Total synthesis of unnatural enantiomer renews interest in quinine
Scientists hope their strategy will invigorate cinchona alkaloid-mimic catalysis
-
Research
Biomimetic synthesis cultivates yellow poppy pigment
Cascade process that fuses indole with orientalin verifies biosynthesis of nudicaulins
-
Opinion
(±)-Rhabdastrellic acid A
A triterpene that looks innocuous until it reveals the highly strained conformation of its rings
-
Research
First synthesis of unusual natural product could revive forgotten eco-friendly insecticide class
16-step synthesis of rare diterpene could reveal new ways to control insecticide-resistant pests
-
Opinion
(+)-Microladallene B
A weird structure is enough to spark chemists’ interest, even without any obvious use
-
-
Opinion
We’re going to need a bigger flask
Scaling up reactions is easy to get wrong in a variety of ways
-
Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
-
Research
Patent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
-
Research
Computation trick cuts total synthesis from 27 to nine steps
Quantum mechanical modelling shows speedy route to terpene natural product
-
-
-
Research
American Civil War era tea yields modern day medicine
Macrocyclisation strategy key to obtaining long known alkaloid with untapped potential
-
-
Opinion
Changing the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
-
Research
What’s left isn’t always right in total synthesis
Scientists turn detective to solve a decade-old stereochemical enigma
