Total synthesis
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ResearchPatent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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ResearchComputation trick cuts total synthesis from 27 to nine steps
Quantum mechanical modelling shows speedy route to terpene natural product
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ResearchAmerican Civil War era tea yields modern day medicine
Macrocyclisation strategy key to obtaining long known alkaloid with untapped potential
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OpinionChanging the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
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ResearchWhat’s left isn’t always right in total synthesis
Scientists turn detective to solve a decade-old stereochemical enigma
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OpinionNatural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
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Opinion(‒)-Pavidolide B
An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis
