All Total synthesis articles
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ResearchTotal synthesis of unnatural enantiomer renews interest in quinine
Scientists hope their strategy will invigorate cinchona alkaloid-mimic catalysis
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Research
Biomimetic synthesis cultivates yellow poppy pigment
Cascade process that fuses indole with orientalin verifies biosynthesis of nudicaulins
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Opinion
(±)-Rhabdastrellic acid A
A triterpene that looks innocuous until it reveals the highly strained conformation of its rings
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Research
First synthesis of unusual natural product could revive forgotten eco-friendly insecticide class
16-step synthesis of rare diterpene could reveal new ways to control insecticide-resistant pests
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Opinion
(+)-Microladallene B
A weird structure is enough to spark chemists’ interest, even without any obvious use
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Opinion
We’re going to need a bigger flask
Scaling up reactions is easy to get wrong in a variety of ways
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Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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Research
Patent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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Research
Computation trick cuts total synthesis from 27 to nine steps
Quantum mechanical modelling shows speedy route to terpene natural product
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Research
American Civil War era tea yields modern day medicine
Macrocyclisation strategy key to obtaining long known alkaloid with untapped potential
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Opinion
Changing the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
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Research
What’s left isn’t always right in total synthesis
Scientists turn detective to solve a decade-old stereochemical enigma
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Opinion
Natural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
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Opinion
(‒)-Pavidolide B
An innovative approach to making five-membered carbon rings makes for a strikingly short synthesis
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Research
Route to fiendishly complex marine molecule cut in half
Shortcut to promising natural product already in Alzheimer’s and HIV trials
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Opinion
Forcing fluorines into shape
Sometimes unnatural molecules can be more challenging to synthesise than natural metabolites
