All Total synthesis articles
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FeatureEditing the structure of molecules
Nina Notman meets the chemists expanding the toolbox of reactions capable of adding, deleting and switching single atoms in rings at the heart of organic molecules
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Research
Streamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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Research
Chirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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Research
Controversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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Opinion
Catalogues of complexity
The tangled web of fine chemicals supply frequently throws up surprises
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Opinion
Exit strategy
Overcoming a major setback showed Derek Lowe could make it through graduate school
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Opinion
Fully automated synthesis of fluorine-18 PET tracers
Making radioisotopes suitable for positron emission tomography
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Opinion
Theodora Greene’s protecting groups
Katrina Krämer uncovers the woman behind the book on every organic chemist’s shelf
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Research
Chemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies
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Research
‘Inside-out’ chirality discovered by chance could have been missed in many molecules
A structure assignment odyssey finds a natural product with a type of isomerism never before seen in small molecules
