All Total synthesis articles
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Opinion
Fully automated synthesis of fluorine-18 PET tracers
Making radioisotopes suitable for positron emission tomography
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Opinion
Theodora Greene’s protecting groups
Katrina Krämer uncovers the woman behind the book on every organic chemist’s shelf
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Research
Chemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies
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Research
‘Inside-out’ chirality discovered by chance could have been missed in many molecules
A structure assignment odyssey finds a natural product with a type of isomerism never before seen in small molecules
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Research
Program finds 5 million synthetic routes to complex chemicals
Only around five hundred ‘tactical combinations’ for advanced organic synthesis existed – until Chematica was let loose on the problem
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Research
Total synthesis of H. pylori antigen creates starting point for gastric cancer vaccine
Remote participation strategy helps chemists make sterically-congested repeating fragment
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Research
Total synthesis of unnatural enantiomer renews interest in quinine
Scientists hope their strategy will invigorate cinchona alkaloid-mimic catalysis
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Research
Biomimetic synthesis cultivates yellow poppy pigment
Cascade process that fuses indole with orientalin verifies biosynthesis of nudicaulins
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Opinion
(±)-Rhabdastrellic acid A
A triterpene that looks innocuous until it reveals the highly strained conformation of its rings
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Research
First synthesis of unusual natural product could revive forgotten eco-friendly insecticide class
16-step synthesis of rare diterpene could reveal new ways to control insecticide-resistant pests
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Opinion
(+)-Microladallene B
A weird structure is enough to spark chemists’ interest, even without any obvious use
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Opinion
We’re going to need a bigger flask
Scaling up reactions is easy to get wrong in a variety of ways
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Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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Research
Patent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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Research
Computation trick cuts total synthesis from 27 to nine steps
Quantum mechanical modelling shows speedy route to terpene natural product
