Total synthesis
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OpinionWe’re going to need a bigger flask
Scaling up reactions is easy to get wrong in a variety of ways
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ResearchThe five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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ResearchPatent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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ResearchComputation trick cuts total synthesis from 27 to nine steps
Quantum mechanical modelling shows speedy route to terpene natural product
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ResearchAmerican Civil War era tea yields modern day medicine
Macrocyclisation strategy key to obtaining long known alkaloid with untapped potential
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OpinionChanging the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take