All C-H activation articles
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ResearchClever ligand design enables alcohol-directed C-H activation
Despite being the most common functional group in nature alcohols have proven difficult to functionalise
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ResearchFrustrated radical pairs cleave unactivated C–H bonds
New technique targets previously inaccessible bonds for selective C–H activation
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ResearchCharge-transfer interactions during C–H activation directly observed
New insights could guide the design of better catalysts
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ResearchElusive formyloxyl radical hints at unique, and more sustainable, chemical transformations
An electrocatalytic route for forming the formyloxyl radical in situ enables researchers to probe its unexpected chemistry
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ResearchIridium pincer complex promotes unprecedented ether decarbonylation
Scientists stumble upon unique transformation that involves breaking an extraordinary number of bonds
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FeatureHomogeneous C–H activation
In the final instalment of our grails series we look at how picking and choosing which bond to target holds the promise of transforming organic molecules at will
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ResearchDNA-compatible C–H activation method set to benefit drug discovery
Larger and more diverse DNA-encoded libraries on the cards thanks to new tool
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ResearchPhotocatalysis in flow makes carbon bonds from nearly inert natural gases
C–H activating methane, ethane and propane in a flow reactor shows that it’s possible to use gaseous hydrocarbons as reagents in organic synthesis
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ResearchCatalyst breaks only molecules’ toughest C–H bonds
Level up for borylation with catalyst that targets molecules’ least reactive carbon–hydrogen bond
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ResearchMethod decorates cubane with multiple aromatic groups
Di-, tri- and tetra-arylcubanes created by directed ortho-C–H metalation and palladium-catalysed cross-coupling
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OpinionExploring nickel reactivity in C–H activation chemistry
Coming closer to an alternative for palladium
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ResearchSupramolecular mask simplifies fullerene modification
Porphyrin structure makes it easier to perform selective reactions on fullerene substrates
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ResearchC–H fluoroalkylation tackles plastic waste
Photocatalytic method that upcycles aromatic polymers could breathe new life into rubbish
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ResearchEnzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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ResearchFlexible route to enantiomerically enriched cyclobutanes
System for modifying square starting molecule could be gateway to numerous bioactive molecules
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ResearchEnzyme evolved that can perform reactions new to nature
New possibilities for organic synthesis with enzymatic C–H functionalisation
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ResearchNew tools direct reactions at specific C–H bonds in organic molecules
Elegant catalysts offer quicker routes to complex compounds
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OpinionKetones perform at the palladium
C–H activation takes the stress out of organometallic couplings
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ResearchCatalyst sets sights on C–H sites
New catalyst stereoselectively functionalises unactivated C–H bonds
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NewsChemistry Nobel predictions range from perovskites to Crispr
Clarivate’s citation laureates name C–H functionalisation, perovskites and catalysis as Nobel contenders, while others favour Crispr or batteries