Catalyst breaks only molecules’ toughest C–H bonds

An image showing the tert-butyl ester of dehydroabietic acid

Level up for borylation with catalyst that targets molecules’ least reactive carbon–hydrogen bond

‘There’s simply no other reaction in chemistry that will functionalise that carbon–hydrogen bond,’ says John Hartwig from the University of California, Berkeley, in the US about his team’s discovery: a catalyst that tackles the least reactive bond in a molecule. The reaction replaces the strongest primary C–H bond with a boron group.