All cross coupling reactions articles
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SponsoredCatalysing change: innovative solutions for greener chemistries
New ligands are enabling the enormous potential of cross coupling reactions to solve challenges in a range of industries
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Opinion
Embracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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Research
AI discovers the best general conditions yet for cross couplings, doubling yields
Algorithm works with robotic experimenter on tricky Suzuki–Miyaura reactions
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Sponsored
Next-generation ligands for complex coupling challenges
Improving phosphines for metal catalysis can deliver more efficient and sustainable syntheses
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Research
Artificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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News
The curious incident of the catalytic amine that never was
A series of unfortunate events and a missed control experiment meant palladium sneaked its way into a supposedly amine-catalysed reaction
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News
Chemistry Nobel laureate Ei-ichi Negishi dies at 85
Discoverer of the Negishi coupling, who did synthetic organic chemistry research at Purdue for four decades, has passed away
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Research
Zinc a double-edged sword when it comes to nickel catalysis
Mechanistic studies shed light on the role of zinc salts in cross-coupling reactions
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Research
Amine might end palladium’s reign over classic cross coupling reaction
Suzuki reaction now comes in an organocatalysed format
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Research
Big data behind cheat sheets for optimising Buchwald–Hartwig cross-couplings
Interactive tools based on data from 62,000 reactions could help chemists eliminate human biases when selecting reaction conditions
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Research
Carbon bond formation reproducibility runs into reagent stability problem
Solid sodium alkoxides react with carbon dioxide and can hamper performance – but sometimes improve it
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Research
Aniline synthesis turns to photochemistry to access challenging targets
New photochemical strategy could jump in where common cross-coupling reactions fall short
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Research
Microfluidic electrochemistry delivers radical coupling breakthrough
Interelectrode gap engineered so that diffusion outpaces radical decomposition
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Opinion
Taking benzyl fluorides beyond game changing reports
Decarboxylative cross-coupling to produce benzyl fluorides
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Opinion
Stille cross-coupling
Palladium and tin combined to lay the foundations for a revolution in C–C bond-forming reactions
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Research
Minty-fresh solvent for sustainable cross-couplings
Eucalyptol could replace diethyl ether, DMF, THF and toluene in many synthetic reactions
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Research
Ligand selector steers C–N cross-couplings down most sustainable path
Tool is step towards strategy that considers reagents and reactants above and below the arrow
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Sponsored
Creating carbon–carbon bonds via transition metal catalysis
Cross-coupling and metathesis reactions are powerful ways of making carbon–carbon bonds, the crucial links behind most organic compounds
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Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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Opinion
In search of ultimate selectivity
A catalyst that reacts only with aryl iodides, spurning bromides and chlorides
