All cross coupling reactions articles
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ResearchBig data behind cheat sheets for optimising Buchwald–Hartwig cross-couplings
Interactive tools based on data from 62,000 reactions could help chemists eliminate human biases when selecting reaction conditions
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Research
Carbon bond formation reproducibility runs into reagent stability problem
Solid sodium alkoxides react with carbon dioxide and can hamper performance – but sometimes improve it
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Research
Aniline synthesis turns to photochemistry to access challenging targets
New photochemical strategy could jump in where common cross-coupling reactions fall short
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Research
Microfluidic electrochemistry delivers radical coupling breakthrough
Interelectrode gap engineered so that diffusion outpaces radical decomposition
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Opinion
Taking benzyl fluorides beyond game changing reports
Decarboxylative cross-coupling to produce benzyl fluorides
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Opinion
Stille cross-coupling
Palladium and tin combined to lay the foundations for a revolution in C–C bond-forming reactions
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Research
Minty-fresh solvent for sustainable cross-couplings
Eucalyptol could replace diethyl ether, DMF, THF and toluene in many synthetic reactions
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Research
Ligand selector steers C–N cross-couplings down most sustainable path
Tool is step towards strategy that considers reagents and reactants above and below the arrow
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Sponsored
Creating carbon–carbon bonds via transition metal catalysis
Cross-coupling and metathesis reactions are powerful ways of making carbon–carbon bonds, the crucial links behind most organic compounds
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Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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Opinion
In search of ultimate selectivity
A catalyst that reacts only with aryl iodides, spurning bromides and chlorides
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Research
Phosphorus beats palladium in connecting nitrogen rings
An entirely metal-free reaction goes where no traditional cross-coupling has gone before – to link pyridines
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Research
Robots explore chemistry’s dark spaces
Thousands of nanoscale experiments create map of reactions that don’t work
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Research
Machine learning triumphs in tough cross coupling challenge
5000 nanoscale experiments teach algorithm how to predict outcomes of reactions in the presence of inhibitors
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Research
1500 reactions per day go with the flow
Automated flow chemistry system puts high-speed spin on drug discovery
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Research
'Robo-chemist' optimises reactions in one day
Intelligent automated reactor drastically cuts time it takes to optimise cross-coupling reactions
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Research
Elusive Suzuki intermediates finally captured
Backing for model that ‘jumped straight into textbooks’ without any experimental evidence
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Research
Complex amines made easy (and cheap)
Iron-catalysed cross-coupling brings together nitroarenes and olefins in a single step in boon for drug makers
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Research
Carbon–carbon couplings go 3D
Reaction extends 2010 Nobel prize winning Suzuki coupling and can be used to modify natural products
