Microfluidic electrochemistry delivers radical coupling breakthrough

An image showing a fully electrochemical two-step synthesis of liquid crystal material 5CB

Source: © Science/AAAS

Interelectrode gap engineered so that diffusion outpaces radical decomposition

Photoredox catalysis has opened many doors in organic synthesis in the past decade, enabling the small-scale synthesis of many compounds that are otherwise difficult or impossible to produce. It is problematic above laboratory scale, however. Now researchers in the US present a microfluidic flow cell that can synthesise many of the same molecules as photoredox catalysis, and potentially others. They demonstrate the method’s viability by performing key chemical transformations and synthesising a liquid crystal used in LCDs.