A current take on the Swern oxidation

A diagram showing a sulphide group turned positive by electrochemistry ning to oxidise an alcohol group

Source: © Kevin Lam/University of Greenwich

Electrochemical update to a classic reaction trades cryogenic conditions for room temperature, to selectively convert primary and secondary alcohols into aldehydes and ketones

An electrochemical reaction that selectively oxidises primary and secondary alcohols into their corresponding aldehydes and ketones at room temperature offers a contemporary twist on the classic Swern oxidation. This electrified version of the organic chemistry textbook staple, which uses dimethyl sulfide as a redox mediator, can be scaled up in flow conditions without risking over-oxidation, and avoids the cryogenic temperatures and hazardous reagents required by its predecessor.