An end to incorrect NMR structures?
An adapted protein NMR technique could avoid the structures of complex molecules having to be revisited
Nuclear Magnetic Resonance (NMR) spectroscopy is perhaps the most useful technique for determining the structures of molecules that do not form suitable crystals for x-ray crystallography. However, it has been known to produce incorrect structures, particularly for complex molecules. But now researchers at Merck & Co., along with academic partners in the US and the Netherlands, have adapted a method more commonly used in biological studies so that it can be used to check whether a proposed structure is correct, or pick the right candidate from several possible structures.