First direct chemical synthesis of a gene over 1700 nucleotides long

 Direct chemical synthesis has been adapted to make oligonucleotides of remarkable length, including an 800 nucleotide green fluorescent protein gene and a 1728 nucleotide bacteriophage DNA polymerase gene. Potentially this technique could be used to synthesise oligonucleotides containing features such as long repeats or unusually stable higher-order structures, which are currently a challenge.