Mechanochemistry bypasses need for solvents in Suzuki coupling
Adding a small amount of olefin dramatically improves challenging solid-state coupling reaction
Scientists in Japan have established a way to drive Suzuki–Miyaura cross-coupling reactions with ball milling mechanochemistry. The scalable method works on a broad range of substrates and provides a way to connect poorly soluble substrates to make complex polyaromatic hydrocarbons in an environmentally friendly way.