PEGylated ligands boost speed and selectivity in mechanochemical arylations

Pyridine-based ligands designed for mechanochemical conditions have dramatically cut the reaction time of a series of solvent-free palladium-catalysed conjugate arylation reactions. In addition to enhancing catalytic activity, the ligands also improved the stereoselectivity of the reactions, underscoring the impact of tailoring ligand design to the unique demands of mechanochemical environments.