All organic synthesis articles
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ResearchCross-coupling technique cracks open alcohols for chemical synthesis
A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists
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ResearchFully automated synthesis robot sets new record in stereospecific carbon–carbon bond formation
The robotic platform can make six carbon–carbon bonds without human guidance
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FeatureWiring up organic synthesis
James Mitchell Crow talks to the organic chemists using electrochemistry to add or remove electrons to their molecules at the flick of a switch
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ResearchMachine-learning software competes with human experts to optimise organic reactions
Researchers say the tool is an inexpensive approach to yield optimisation for chemistry labs that can’t afford robots
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ResearchMachine-designed natural product syntheses pass ‘Turing test’ for chemistry
Software updates allow Chematica to design sophisticated synthetic pathways, planning each step four or five moves ahead
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OpinionNeil Garg: ‘My brain is always turning’
The synthetic chemist and communicator on parenting and putting on a show
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ResearchAre synthetic chemists out of a job as AI meets automation?
Platform can weigh up a synthetic route, plan it and then carry out it
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ResearchBaran and Blackmond team up to wave farewell to tough ether syntheses
Oxidative decarboxylation produces carbocations that greatly speed up hindered ether production
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OpinionWhat molecules should we make with a chemputer robot?
Digitising organic synthesis could revolutionise life in the lab
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ResearchThe five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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OpinionIn search of ultimate selectivity
A catalyst that reacts only with aryl iodides, spurning bromides and chlorides
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ResearchPatent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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WebinarSynthia – retrosynthetic design software for practising chemists
See a technology overview of Synthia and its use in synthetic design. The webinar includes a live demo and an explanation of the licensing and service models available
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FeatureDerek Barton and shape-shifting molecules
It’s 100 years since Derek Barton was born. Mike Sutton looks at his work developing conformational analysis
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OpinionA sideways look at synthesis
Side products might not be what you want, but they could be what you need
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ResearchLongest ever graphene nanoribbon made
Iterative synthesis makes nanoribbons that are nearly 8nm long
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ResearchElectric shock brings diamines to life
A combination of electrochemistry and organic catalysis transforms alkenes into hard-to-make vicinal diamines
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ResearchStructural sleuthing salvages superbug slayer
Combining ‘assembly line’ synthesis, spectroscopy and computational predictions solves stereochemistry riddle
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BusinessMerck KGaA to buy Chematica
Retrosynthesis tool will gain computational muscle and integrate with Sigma–Aldrich catalogue
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OpinionFunctionalising pyridines with phosphonium salts
Newly-independent research groups often bring new perspectives to synthesis