Disease – Page 6
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ResearchCrispr treatment reverses muscular dystrophy in mice
Upregulated gene triggers laminin-α1 protein production, reviving paralysed limbs
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PodcastAzidothymidine
The first drug approved in the US to treat Aids required a completely new approach to clinical trials – Frances Addison explores the history of azidothymidine
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PodcastAmantadine
Katrina Krämer investigates how one of the smallest small molecule drugs around saved Jeanna Giese's life
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PodcastLevothyroxine
Kit Chapman investigates the drug that has been one of the top five prescription medications in the UK every year for the last two decades
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NewsPilot malaria vaccination programme begins in Malawi
Mosquirix vaccine will be rolled out in Ghana and Kenya next week
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BusinessBuilding a biological biocide
Aqualution Systems produces stable hypochlorous acid, a natural biocide up to 300 times more effective than bleach
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ResearchSynthetic enzyme wipes out tough bacterial biofilms
After success in mice strategy could be an alternative to antibiotics to treat wounds
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ResearchHole-punching antifungal used as molecular prosthesis for cystic fibrosis
Drug creates artificial ion channels that could replace broken version in cystic fibrosis patients’ lung cells
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PodcastVinblastine and vincristine: Vinca alkaloids
Kat Arney unearths a story of an overlooked female researcher in the search for the origins of cancer drugs found in plants
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ResearchCracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
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NewsGenome sequencing for healthy dismissed as waste of time for UK project
Personalised medicine plan unlikely to deliver any benefits for the wider population
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ResearchTwo flavouring chemicals prevalent in e-cigarettes might harm lung function
Diacetyl and 2,3-pentanedione suppress gene expression related to cilia production and function
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PodcastMelarsoprol
Cases of sleeping sickness – human African trypanosomiasis – are in decline, dropping 86% in Africa between 2000 and 2014. Gege Li explores the role that this toxic, arsenic-based medication has to play.
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NewsPersonalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
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ResearchAlzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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ResearchBlood pressure drug reacts with membrane lipids
Lipidation products add to evidence that biological membranes are far from chemically inert