Medicine and health
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Research
Screening reveals thousands of ‘undrugged, yet druggable’ proteins
Collaboration involving Pfizer develops freely accessible AI tool to probe protein–compound interactions
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Research
Study raises questions about media used for in vitro tests on nanomaterials
Multiomics profiling details how biomolecular corona that form in conventional cell culture differ to those that form in human plasma
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Research
New mechanism identified that is potentially linked to very early stages of Alzheimer’s
Understanding role of fragments of amyloid protein could lead to novel therapies for the disease
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Research
Could mechanochemistry have saved Abbott Laboratories $250 million?
Ball milling solves problem of disappearing ritonavir polymorph
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Research
Certain household chemicals could pose a threat to brain health, research suggests
Cell and animal tests suggest two classes of common chemicals might play a role in neurological disease
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Research
Cross-coupling technique cracks open alcohols for chemical synthesis
A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists
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Research
Non-antibiotics with antibacterial activity could help in the fight against antimicrobial resistance
New analysis shows that non-antibiotic drugs kill bacteria through mechanisms that differ from those of conventional antibiotics
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Research
Classic cross-coupling reactions rerouted to make new products
Combination of Suzuki–Miyaura and Buchwald–Hartwig couplings produces carbon–nitrogen–carbon linked compounds
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Research
Pre-organising antibiotic structure could aid fight against resistance
Strategy that produced new antibiotic could allow researchers to repurpose existing antibiotics
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Research
Heavy metals are potential ovarian toxicants
Exposure to metals like arsenic, cadmium and mercury linked to reduced egg production, earlier menopause for middle-aged women
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Research
Rare medical transmission of Alzheimer’s disease from donor to patient discovered
Human growth hormone extracted from cadavers passed disease protein to at least five people
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Research
Unravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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Research
Steroid separation made easy with photoswitchable coordination cage
Light-activated coordination cage purifies progesterone
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Research
PFAS linked to foetal metabolism disorders
‘Forever chemicals’ in the livers of unborn children can alter lipid metabolism and may increase the risk of metabolic disease in adulthood
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Research
D-trypsin synthesis enables sequencing of mirror-image proteins
Reversing the chirality of a protein-digesting enzyme could aid the development of mirror-image therapeutics
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Research
Machine learning identifies promising antibacterial ruthenium-based drug candidates
Algorithm demonstrated a success rate six times higher than a random screening against resistant bacteria
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Research
Biocatalysis breakthrough enables synthesis of lactam building blocks for drugs
Enzymatic cyclisation of oxazolone reagents offers a cheap and simple route to important antibiotic precursor
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Research
Nanopore test could identify misfolded proteins in Alzheimer’s and Parkinson’s disease
Sensor could provide more accurate diagnoses and help doctors track progress of neurodegenerative diseases
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Research
Antibiotic adjuvant designed to subvert bacterial defence mechanisms
Amphiphilic molecule helps obsolete antibiotics accumulate and act within bacteria
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Research
New insights into polyamorphism could influence how drugs are formulated
Findings suggest dihedral angle distribution might explain why polyamorphs have different physical properties