AI method makes designer binders for ‘undruggable’ proteins
Technique can create molecules that target disordered regions of proteins and peptides
Researchers behind a new AI-assisted technique that designs binding proteins to latch onto previously inaccessible drug targets are calling it a ‘major breakthrough’ in protein design. By targeting intrinsically disordered protein regions, which are common and often have roles in disease, including cancer and neurodegenerative conditions, the approach could pave the way for new treatments and diagnostic tools.