Computational study says nucleophile finds σ-holes more attractive than π-holes

Pop art style illustration of sigma and pi holes

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A σ-hole leads to a stronger bond with NH3 than a π-hole on the same atom

Theoretical work investigating the ability of σ- and π-holes located on the same atom to engage in non-covalent bonds shows that a nucleophile is preferentially attracted to the σ-hole.