Molecular cryo-EM discovers error in 25-year-old natural product structure
Nobel prize-winning biomolecule imaging technique adapted to characterise chemical compounds faster and easier than NMR and x-ray
Researchers in the US have combined genome mining with a type of cryo-electron microscopy to discover new natural products and their structures – even correcting the structure of a natural product first isolated 25 years ago. The technique is faster and overcomes limitations of other methods like nuclear magnetic resonance (NMR) and x-ray crystallography, so it could boost drug and agrochemical discovery.