Reaction mechanisms – Page 2
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ResearchExploiting evolution to explore chemical space shows promise for drug discovery
Using molecular trees – similar to family trees – chemists could predict how products will evolve to make new molecules
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ResearchMöbius metallacycles show their aromaticity with textbook reactivity
First electrophilic aromatic substitution reactions with unusual molecules
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ResearchBlue light squeezes out heteroatoms from small rings
Photochemical ring editing reaction allows complete molecular shape change in a single step
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ResearchTransient spectroscopy sheds light on elusive photoredox process
Study confirms mechanism of sensitisation-initiated electron transfer reaction following extended debate
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ResearchChemists control reaction path with mechanical force
Mechanochemical mechanism exploited to access unconventional trajectories on a reaction’s potential energy surface
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ResearchSynthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
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ResearchIodine revealed to be killer species that destroys tin-based perovskites
New insights into the mechanism that inactivates tin solar cells could lead to greener, more efficient devices
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OpinionFree radicals for post-translational modification
A technique for forming new carbon–carbon bonds at specific sites in proteins
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ResearchReaction confined between copper nanopyramids transforms carbon dioxide into ethylene glycol
Copper arrangement promotes C–C coupling and lowers formation barrier for a key intermediate
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ResearchRe-evaluating pyridine’s role in chlorination reaction
Well-established mechanism for chlorination using dichloroiodobenzene together with pyridine proven wrong
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ResearchNitrogen deletion reaction offers ‘new way to think about molecular editing’
Reagent inspired by decades-old research could save chemists a lot of headache when it comes to modifying molecules’ skeleton
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ResearchAlkali cations boost carbon dioxide reduction into feedstock chemical
Discovery enables continuous-flow electrolysers with industrial potential
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NewsBots bring chemistry research tools to Twitter
Cheminformatic tool can deliver retrosynthetic analysis
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ResearchSupramolecular cage unlocks mild aldehyde reduction strategy
Computational analysis reveals how encapsulation stabilises protonated oxocarbenium ion of furfural, which makes the carbonyl moiety easier to reduce
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OpinionSpace, energy and synthetic half-reactions
Matching driving forces with intermediates to predict new chemistry
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ResearchNitrogen radical chemistry sees the light
Daniele Leonori explains how his group is taking inspiration from 30-year-old chemistry to devise shorter syntheses for bioactive compounds
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ResearchSurface chemistry discovery points way to cheaper water splitting
New experiments reveal the true mechanism of electrocatalysed oxygen evolution reaction
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ResearchHammett equation parameters optimised for improved predictive power
Update overcomes limitations and eliminates human biases intrinsic to the original formulation
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FeatureDirect observation of the transition state
The mystery of precisely what happens when one chemical reacts to form a new one is now being revealed in ever greater detail
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ResearchRetro-Diels–Alder study links solvent viscosity to reaction rate under microwave heating
New study helps to establish the parameters for microwave-specific rate enhancements observed in certain reactions