Drug discovery and development
The latest chemistry news and research on drug discovery and development, including cancer drugs, antibiotics, vaccines and drug screening, from the Royal Society of Chemistry's magazine, Chemistry World
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News
Explainer: nitazenes and xylazine – a cause for concern
Why is the use of these highly potent synthetic drugs rising dramatically?
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Research
Cross-coupling technique cracks open alcohols for chemical synthesis
A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists
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Research
Non-antibiotics with antibacterial activity could help in the fight against antimicrobial resistance
New analysis shows that non-antibiotic drugs kill bacteria through mechanisms that differ from those of conventional antibiotics
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Opinion
Harnessing biodiversity through natural products research in the Philippines
Collaborative projects aim to produce cheaper and more effective medicines
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Research
Classic cross-coupling reactions rerouted to make new products
Combination of Suzuki–Miyaura and Buchwald–Hartwig couplings produces carbon–nitrogen–carbon linked compounds
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Opinion
From one sinking ship to another?
Biogen abandoning Alzheimer’s antibody aducanumab is unusual, but hardly surprising, says Derek Lowe
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Business
Big deals confirm renewed interest in radiopharmaceuticals
Acquisitions of RayzeBio and Point Biopharma highlight the potential of targeting radioactivity directly to tumour cells
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Research
Pre-organising antibiotic structure could aid fight against resistance
Strategy that produced new antibiotic could allow researchers to repurpose existing antibiotics
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Feature
More than a mirror-image: left-handed nucleic acids
Now a biological reality, researchers are starting to figure out the many roles of left-handed nucleic acids such as Z-DNA – from immunity to controlling our genetics. Rachel Brazil reports
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Research
Unravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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Research
D-trypsin synthesis enables sequencing of mirror-image proteins
Reversing the chirality of a protein-digesting enzyme could aid the development of mirror-image therapeutics
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Business
New Covid-19 antiviral cuts symptoms by 1.5 days
Simnotrelvir already has emergency approval in China
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News
Explainer: A new antibiotic class has been discovered – how excited should we get?
With 10 million people a year forecast to die a year as a result of antimicrobial resistance by 2050 many new antibiotics are urgently needed
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Research
Machine learning identifies promising antibacterial ruthenium-based drug candidates
Algorithm demonstrated a success rate six times higher than a random screening against resistant bacteria
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Opinion
Exploring new fragments of chemical space
How medicinal and process chemists are working together to build better drugs
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Business
Pharmaceuticals roundup 2023
Regulatory and pricing reforms have topped industry agendas in 2023, while weight loss drugs surged and Covid-19 therapies waned
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Feature
Cubanes help drugs take the strain
Medicinal chemists are increasingly exploring strained ring systems, George Barsted reports, believing they can serve as replacements for conventional building blocks in pharmaceuticals
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Research
Antibiotic adjuvant designed to subvert bacterial defence mechanisms
Amphiphilic molecule helps obsolete antibiotics accumulate and act within bacteria
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Business
Weight-loss drug shortages prompt copycats and counterfeits
Novo Nordisk and Eli Lilly have struggled to meet huge demand for new hormone mimic obesity treatments