Drug discovery and development – Page 19
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PodcastAmantadine
Katrina Krämer investigates how one of the smallest small molecule drugs around saved Jeanna Giese's life
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WebinarMiniaturise the haystack: DNA-Encoded Libraries for drug discovery
A DNA-Encoded Library (DEL) case study and fragment-based DEL discovery insight from DyNAbind
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BusinessUS finalises guidance on biosimilars
Regulator clarifies requirements for allowing substitution between products
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ResearchTrefoil knots steer cancer drug leads in fresh direction
Chemists look to links and knots in the search for new cancer therapies
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FeatureChanging the locks
Designer receptors help understand cellular signals and could treat epilepsy and Parkinson’s disease, but need new tools, finds Andy Extance
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PodcastMethylphenidate (Ritalin)
Jamie Durrani diverts his attention to the rise of Ritalin, a drug first identified as a way of improving tennis performance
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FeatureMalaria no more?
Efforts to cure malaria have been going on for hundreds of years. Clare Sansom looks at some of the latest – and most innovative
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NewsPilot malaria vaccination programme begins in Malawi
Mosquirix vaccine will be rolled out in Ghana and Kenya next week
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ResearchSynthetic enzyme wipes out tough bacterial biofilms
After success in mice strategy could be an alternative to antibiotics to treat wounds
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ResearchDroplet screening set to accelerate immunotherapies into the clinic
Single-cell technique eliminates inefficiencies when identifying immune cells active against specific cancers
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ResearchCo-crystals fish out cannabinoid from plant extract
Purifying cannabidiol from natural cannabis extract made cheap and easy thanks to amino acid partner
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ResearchNew family of peptides from extremophile show antibiotic promise
Scientists isolate salinipeptins from a bacterium living in America’s Dead Sea
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ArticleSmall particles making a big splash in clinical development
Nanoform is investigating how to tackle clinical attrition rates through nanonisation of APIs
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ArticleInvestigating multi-dimensional problems in drug substance development
Finding solutions to the biggest challenges faced during drug substance development relies on properly integrating analytical and production expertise
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ResearchSmall molecule finds flu virus’s weak spot
Drug candidate that targets highly conserved region of virus gave mice complete protection from swine flu
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FeatureThe battle to lose weight
Losing weight – and not putting it back on – is about much more than willpower. Nina Notman reports on the drugs trying to penetrate the complex metabolic web of hunger and satiety.
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ResearchCracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
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ResearchGenetically engineered yeast brews up heady mix of natural and unnatural cannabinoids
Biotech yeast makes low-cost, high-quality THC and CBD – and cannabinoids never seen before – without growing cannabis plants