Drug discovery and development – Page 20
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ResearchThe five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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FeaturePass the antidote
From paracetamol to pesticides – not to mention nerve agents – there are many toxic compounds that doctors need to be able to counteract. Nina Notman investigates
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NewsPersonalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
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OpinionHow teenagers are disrupting drug discovery
A citizen science project to improve access to malaria drugs
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BusinessUK government sets out antimicrobial resistance plan
Aims to cut antibiotic use and explore financial incentives for pharmaceutical companies
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FeatureCan we live forever?
We are now living longer than ever before, but not always in perfect health. Anthony King talks to the researchers working to extend our healthspan
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ResearchAlzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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ResearchScreening strategy pursues photocatalytic couplings for drug discovery
High-throughput screening and flow-based scale-up combo identifies chemistry needed to functionalise drug fragments and obtain useful amounts of product
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OpinionWhat are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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ResearchCrowdsourced drug discovery pits half-forgotten compounds against neglected diseases
45 research groups donate 350 compounds to the first crowdsourced screening library
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ResearchNanodecoys lure and trap Zika virus
Gelatin nanoparticles camouflaged by mosquito membrane mop up virus and stop it crossing placenta
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ResearchErythropoietin benefits from controlled sugar-coating
Click chemistry allows glycosylation at virtually any synthetic stage
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NewsX-ray crystallographer to oversee Rosalind Franklin Institute
Structural biologist James Naismith to become first director of UK’s new national life sciences institute
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BusinessBreaking the silence of RNA interference drugs
A wave of treatments is set to follow the first approval of an RNAi therapy
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ResearchFirst oral antibiotic booster for four decades could tackle drug resistance
Sulfate-masking strategy makes bacterial enzyme inhibitor an easy pill to swallow
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OpinionPassing through checkpoints
A new breed of cancer treatments highlights what’s possible when industry concentrates its efforts
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ResearchNew peptide destroys Zika virus in brain for first time
Engineered molecule ruptures virus particles to tackle infection
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OpinionThe potential of promiscuity
Nobel recognition for a concept whose benefit to humankind is far from being truly realised
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