Drug discovery and development – Page 16
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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PodcastCyclopropane
Chemistry’s tastiest bonds for an explosive anaesthetic that was as useful as it was dangerous
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Podcast2C psychedelics
A class of hallucinogenic phenethylamines, explored by the 'godfather of psychedelics' Alexander Shulgin and sadly implicated in a tragedy at a 2017 music festival
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ResearchColourful antibiotics isolated from scorpion venom
Isolated benzoquinone has excellent activity against TB along with low toxicity in mice
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PodcastAzidothymidine
The first drug approved in the US to treat Aids required a completely new approach to clinical trials – Frances Addison explores the history of azidothymidine
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OpinionIs this a golden age of new drug classes?
A host of new treatment modes are hitting the clinic and the market
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ResearchSpore shell acts as sunscreen for light-sensitive antibiotics
Polymer capsule that protects and preserves antimicrobial compound could aid fight against multi-drug resistant pathogens
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PodcastAmantadine
Katrina Krämer investigates how one of the smallest small molecule drugs around saved Jeanna Giese's life
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WebinarMiniaturise the haystack: DNA-Encoded Libraries for drug discovery
A DNA-Encoded Library (DEL) case study and fragment-based DEL discovery insight from DyNAbind
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BusinessUS finalises guidance on biosimilars
Regulator clarifies requirements for allowing substitution between products
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ResearchTrefoil knots steer cancer drug leads in fresh direction
Chemists look to links and knots in the search for new cancer therapies
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FeatureChanging the locks
Designer receptors help understand cellular signals and could treat epilepsy and Parkinson’s disease, but need new tools, finds Andy Extance
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PodcastMethylphenidate (Ritalin)
Jamie Durrani diverts his attention to the rise of Ritalin, a drug first identified as a way of improving tennis performance
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FeatureMalaria no more?
Efforts to cure malaria have been going on for hundreds of years. Clare Sansom looks at some of the latest – and most innovative
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NewsPilot malaria vaccination programme begins in Malawi
Mosquirix vaccine will be rolled out in Ghana and Kenya next week
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ResearchSynthetic enzyme wipes out tough bacterial biofilms
After success in mice strategy could be an alternative to antibiotics to treat wounds
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ResearchDroplet screening set to accelerate immunotherapies into the clinic
Single-cell technique eliminates inefficiencies when identifying immune cells active against specific cancers
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ResearchCo-crystals fish out cannabinoid from plant extract
Purifying cannabidiol from natural cannabis extract made cheap and easy thanks to amino acid partner