Drug discovery and development – Page 18
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BusinessSixth in a line of Alzheimer’s drugs fails in trials
Treatments designed to stop amyloid peptide formation all seem to cause cognitive impairment rather than prevent it
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ArticleThe importance of solid form science in modern drug development
A recent study suggests that around 40% of drugs with market approval exhibit poor water solubility and although this is not a new problem, solutions like those offered by Johnson Matthey are still relevant to today’s pharma market
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ResearchElusive protein and key to many tropical diseases found after decades of searching
Discovery offers powerful new target to treat trypanosome parasite illnesses that affect millions
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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ResearchRetrosynthetic algorithm broadened to design similar, but different, molecules
Chematica can now design efficient syntheses for large compound libraries
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ArticleAccurate temperature control achieving big results, on a small scale
Radleys’ compact reaction station brings accurate temperature control to chemical scientists managing small-scale experiments
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OpinionAre new drugs better than existing ones?
Should companies be made to change the way they run clinical trials?
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ResearchModified metallohelices show medical potential
Post-assembly click reactions on helical metal complexes produces biological activity akin to that of the arrow poison ouabain
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ArticleMultidisciplinary science kick starts innovation
Nanoform scientists discuss how their diverse personalities and scientific backgrounds foster innovation, helping them tackle problems from different angles, and design better processes
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ArticleThrough the looking glass: a digital future for healthcare
As the digital revolution continues to disrupt even the world’s most established business sectors, the pharmaceutical industry will need to shift and adapt if it is to realise its vision for the future of healthcare
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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PodcastCyclopropane
Chemistry’s tastiest bonds for an explosive anaesthetic that was as useful as it was dangerous
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Podcast2C psychedelics
A class of hallucinogenic phenethylamines, explored by the 'godfather of psychedelics' Alexander Shulgin and sadly implicated in a tragedy at a 2017 music festival
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ResearchColourful antibiotics isolated from scorpion venom
Isolated benzoquinone has excellent activity against TB along with low toxicity in mice
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PodcastAzidothymidine
The first drug approved in the US to treat Aids required a completely new approach to clinical trials – Frances Addison explores the history of azidothymidine
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OpinionIs this a golden age of new drug classes?
A host of new treatment modes are hitting the clinic and the market
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ResearchSpore shell acts as sunscreen for light-sensitive antibiotics
Polymer capsule that protects and preserves antimicrobial compound could aid fight against multi-drug resistant pathogens