Drug discovery and development – Page 18
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ResearchErythropoietin benefits from controlled sugar-coating
Click chemistry allows glycosylation at virtually any synthetic stage
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NewsX-ray crystallographer to oversee Rosalind Franklin Institute
Structural biologist James Naismith to become first director of UK’s new national life sciences institute
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BusinessBreaking the silence of RNA interference drugs
A wave of treatments is set to follow the first approval of an RNAi therapy
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ResearchFirst oral antibiotic booster for four decades could tackle drug resistance
Sulfate-masking strategy makes bacterial enzyme inhibitor an easy pill to swallow
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OpinionPassing through checkpoints
A new breed of cancer treatments highlights what’s possible when industry concentrates its efforts
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ResearchNew peptide destroys Zika virus in brain for first time
Engineered molecule ruptures virus particles to tackle infection
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OpinionThe potential of promiscuity
Nobel recognition for a concept whose benefit to humankind is far from being truly realised
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BusinessCancer immunotherapy spreads rapidly
New approvals and expanded use for checkpoint inhibitor drugs illustrate the power of Nobel-winning science
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FeatureHow chemical evolution took the 2018 chemistry Nobel prize
Emma Stoye has the full story of how Frances Arnold, George Smith and Greg Winter put evolution to work in the lab
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OpinionThe projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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ResearchNanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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BusinessCleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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NewsWhat is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers
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NewsWhat is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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NewsImmune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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BusinessLandmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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ResearchHepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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NewsBitter feuding at Cochrane healthcare audit body paralyses organisation
One member has been expelled from the governing board while another four resign with accusations of pharmaceutical industry bias flying
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ResearchGenentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action