Drug discovery and development – Page 21
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BusinessCancer immunotherapy spreads rapidly
New approvals and expanded use for checkpoint inhibitor drugs illustrate the power of Nobel-winning science
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FeatureHow chemical evolution took the 2018 chemistry Nobel prize
Emma Stoye has the full story of how Frances Arnold, George Smith and Greg Winter put evolution to work in the lab
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OpinionThe projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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ResearchNanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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BusinessCleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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NewsWhat is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers
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NewsWhat is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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NewsImmune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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BusinessLandmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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ResearchHepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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NewsBitter feuding at Cochrane healthcare audit body paralyses organisation
One member has been expelled from the governing board while another four resign with accusations of pharmaceutical industry bias flying
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ResearchGenentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
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OpinionFeeding the confusion
When it comes to working out what foods do to our bodies, mostly we just don’t know
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FeatureThe quest to cure HIV
Although HIV–Aids can now be managed quite well with antiretroviral drugs, there is still no cure. Anthony King talks to the scientists trying to find one
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BusinessUS approves first RNA interference drug
Alnylam’s Onpattro (patisiran) can treat a rare hereditary disease by silencing a specific gene
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ResearchBismuth drugs kill bacteria by disrupting metabolism
Scientists throw kitchen sink of omics techniques at understanding complicated response of prevalent human pathogen to bismuth drug
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FeatureFrom folklore to pharmacy
Although many drugs have in the past come from plants, Hayley Bennett discovers that it’s hard work getting them approved today
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BusinessVaccine scandal and heart drug recall show China’s pharma struggles
Fifteen arrests amid evidence of bribery related to vaccines, despite new standards and penalties for fraud
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BusinessNovartis exit from antibiotics a setback for race against resistance
Experts say business models must change to halt big pharma exodus