Sulfonated macrocycle helps the medicine go down

Terphen[3]arene

Source: © Chunju Li

A supramolecular approach makes alkaloid drugs taste less bitter

Scientists in China have developed a macrocyclic compound that can mask the bitter taste of alkaloid drugs. The water-soluble compound forms a complex with alkaloids but subsequently releases them in the digestive tract, where they can go on to exert their pharmaceutical effect.